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High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease
Background: Premature coronary artery disease (CAD) is a major cause of mortality and morbidity. Increased low-density lipoprotein-cholesterol (LDL-C) level is a major risk factor for CAD and thus the main target for its prevention. Familial Hypercholesterolemia (FH) is a genetic inherited disorder...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538839/ https://www.ncbi.nlm.nih.gov/pubmed/31213876 http://dx.doi.org/10.2147/TACG.S202942 |
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author | Pirazzi, Carlo Håkansson, Lina Gustafsson, Carola Omerovic, Elmir Wiklund, Olov Mancina, Rosellina Margherita |
author_facet | Pirazzi, Carlo Håkansson, Lina Gustafsson, Carola Omerovic, Elmir Wiklund, Olov Mancina, Rosellina Margherita |
author_sort | Pirazzi, Carlo |
collection | PubMed |
description | Background: Premature coronary artery disease (CAD) is a major cause of mortality and morbidity. Increased low-density lipoprotein-cholesterol (LDL-C) level is a major risk factor for CAD and thus the main target for its prevention. Familial Hypercholesterolemia (FH) is a genetic inherited disorder characterized by high LDL-C, and subsequent premature CAD development. Early drug treatment with lipid-lowering medications in FH prevents cardiovascular disease onset. The FH prevalence in the Northern European general population is 0.3%, and it is estimated that it explains 20% of premature CAD cases in individuals with familial clustering. Despite the wide number of papers showing the prevalence of clinical FH in cardiovascular disease, the prevalence of genetic FH in individuals with premature CAD is not yet well known. Here, we examined the prevalence of genetically determined FH in individuals with premature CAD. Patients and methods: 66 patients who underwent coronary angiography with suspected premature acute coronary syndrome (age <50 years for men and <55 years for women) underwent genetic screening to identify FH-causing mutations. All patients underwent physical and clinical examinations. Information about family and personal history, drug therapy and habits were also collected. Results: We found FH-causative mutations in 3/66 (4.5%) screened individuals with premature CAD. When considering individuals with confirmed CAD after coronary angiography, the FH mutation prevalence was 6.1% (3/49). After excluding individuals with classical risk factors for CAD other than hypercholesterolemia, the FH mutation prevalence raised to 15.8% (3/19). Conclusion: In conclusion, we found that individuals with premature CAD have a more than 15-fold increased prevalence of FH mutations compared to the general population. |
format | Online Article Text |
id | pubmed-6538839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-65388392019-06-18 High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease Pirazzi, Carlo Håkansson, Lina Gustafsson, Carola Omerovic, Elmir Wiklund, Olov Mancina, Rosellina Margherita Appl Clin Genet Original Research Background: Premature coronary artery disease (CAD) is a major cause of mortality and morbidity. Increased low-density lipoprotein-cholesterol (LDL-C) level is a major risk factor for CAD and thus the main target for its prevention. Familial Hypercholesterolemia (FH) is a genetic inherited disorder characterized by high LDL-C, and subsequent premature CAD development. Early drug treatment with lipid-lowering medications in FH prevents cardiovascular disease onset. The FH prevalence in the Northern European general population is 0.3%, and it is estimated that it explains 20% of premature CAD cases in individuals with familial clustering. Despite the wide number of papers showing the prevalence of clinical FH in cardiovascular disease, the prevalence of genetic FH in individuals with premature CAD is not yet well known. Here, we examined the prevalence of genetically determined FH in individuals with premature CAD. Patients and methods: 66 patients who underwent coronary angiography with suspected premature acute coronary syndrome (age <50 years for men and <55 years for women) underwent genetic screening to identify FH-causing mutations. All patients underwent physical and clinical examinations. Information about family and personal history, drug therapy and habits were also collected. Results: We found FH-causative mutations in 3/66 (4.5%) screened individuals with premature CAD. When considering individuals with confirmed CAD after coronary angiography, the FH mutation prevalence was 6.1% (3/49). After excluding individuals with classical risk factors for CAD other than hypercholesterolemia, the FH mutation prevalence raised to 15.8% (3/19). Conclusion: In conclusion, we found that individuals with premature CAD have a more than 15-fold increased prevalence of FH mutations compared to the general population. Dove 2019-05-24 /pmc/articles/PMC6538839/ /pubmed/31213876 http://dx.doi.org/10.2147/TACG.S202942 Text en © 2019 Pirazzi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Pirazzi, Carlo Håkansson, Lina Gustafsson, Carola Omerovic, Elmir Wiklund, Olov Mancina, Rosellina Margherita High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease |
title | High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease |
title_full | High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease |
title_fullStr | High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease |
title_full_unstemmed | High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease |
title_short | High prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease |
title_sort | high prevalence of genetic determined familial hypercholesterolemia in premature coronary artery disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538839/ https://www.ncbi.nlm.nih.gov/pubmed/31213876 http://dx.doi.org/10.2147/TACG.S202942 |
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