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A Robust Model for Circadian Redox Oscillations
The circadian clock is an endogenous oscillator that controls daily rhythms in metabolism, physiology, and behavior. Although the timekeeping components differ among species, a common design principle is a transcription-translation negative feedback loop. However, it is becoming clear that other mec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539027/ https://www.ncbi.nlm.nih.gov/pubmed/31086108 http://dx.doi.org/10.3390/ijms20092368 |
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author | del Olmo, Marta Kramer, Achim Herzel, Hanspeter |
author_facet | del Olmo, Marta Kramer, Achim Herzel, Hanspeter |
author_sort | del Olmo, Marta |
collection | PubMed |
description | The circadian clock is an endogenous oscillator that controls daily rhythms in metabolism, physiology, and behavior. Although the timekeeping components differ among species, a common design principle is a transcription-translation negative feedback loop. However, it is becoming clear that other mechanisms can contribute to the generation of 24 h rhythms. Peroxiredoxins (Prxs) exhibit 24 h rhythms in their redox state in all kingdoms of life. In mammalian adrenal gland, heart and brown adipose tissue, such rhythms are generated as a result of an inactivating hyperoxidation reaction that is reduced by coordinated import of sulfiredoxin (Srx) into the mitochondria. However, a quantitative description of the Prx/Srx oscillating system is still missing. We investigate the basic principles that generate mitochondrial Prx/Srx rhythms using computational modeling. We observe that the previously described delay in mitochondrial Srx import, in combination with an appropriate separation of fast and slow reactions, is sufficient to generate robust self-sustained relaxation-like oscillations. We find that our conceptual model can be regarded as a series of three consecutive phases and two temporal switches, highlighting the importance of delayed negative feedback and switches in the generation of oscillations. |
format | Online Article Text |
id | pubmed-6539027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65390272019-06-04 A Robust Model for Circadian Redox Oscillations del Olmo, Marta Kramer, Achim Herzel, Hanspeter Int J Mol Sci Article The circadian clock is an endogenous oscillator that controls daily rhythms in metabolism, physiology, and behavior. Although the timekeeping components differ among species, a common design principle is a transcription-translation negative feedback loop. However, it is becoming clear that other mechanisms can contribute to the generation of 24 h rhythms. Peroxiredoxins (Prxs) exhibit 24 h rhythms in their redox state in all kingdoms of life. In mammalian adrenal gland, heart and brown adipose tissue, such rhythms are generated as a result of an inactivating hyperoxidation reaction that is reduced by coordinated import of sulfiredoxin (Srx) into the mitochondria. However, a quantitative description of the Prx/Srx oscillating system is still missing. We investigate the basic principles that generate mitochondrial Prx/Srx rhythms using computational modeling. We observe that the previously described delay in mitochondrial Srx import, in combination with an appropriate separation of fast and slow reactions, is sufficient to generate robust self-sustained relaxation-like oscillations. We find that our conceptual model can be regarded as a series of three consecutive phases and two temporal switches, highlighting the importance of delayed negative feedback and switches in the generation of oscillations. MDPI 2019-05-13 /pmc/articles/PMC6539027/ /pubmed/31086108 http://dx.doi.org/10.3390/ijms20092368 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article del Olmo, Marta Kramer, Achim Herzel, Hanspeter A Robust Model for Circadian Redox Oscillations |
title | A Robust Model for Circadian Redox Oscillations |
title_full | A Robust Model for Circadian Redox Oscillations |
title_fullStr | A Robust Model for Circadian Redox Oscillations |
title_full_unstemmed | A Robust Model for Circadian Redox Oscillations |
title_short | A Robust Model for Circadian Redox Oscillations |
title_sort | robust model for circadian redox oscillations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539027/ https://www.ncbi.nlm.nih.gov/pubmed/31086108 http://dx.doi.org/10.3390/ijms20092368 |
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