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New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita

As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,...

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Autores principales: Cao, Liang, Shehla, Nuzhat, Tasneem, Shumaila, Cao, Mengru, Sheng, Wenbing, Jian, Yuqing, Li, Bin, Peng, Caiyun, Choudhary, M. Iqbal, Atta-ur-Rahman, Liao, Duan-fang, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539153/
https://www.ncbi.nlm.nih.gov/pubmed/31035334
http://dx.doi.org/10.3390/molecules24091664
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author Cao, Liang
Shehla, Nuzhat
Tasneem, Shumaila
Cao, Mengru
Sheng, Wenbing
Jian, Yuqing
Li, Bin
Peng, Caiyun
Choudhary, M. Iqbal
Atta-ur-Rahman,
Liao, Duan-fang
Wang, Wei
author_facet Cao, Liang
Shehla, Nuzhat
Tasneem, Shumaila
Cao, Mengru
Sheng, Wenbing
Jian, Yuqing
Li, Bin
Peng, Caiyun
Choudhary, M. Iqbal
Atta-ur-Rahman,
Liao, Duan-fang
Wang, Wei
author_sort Cao, Liang
collection PubMed
description As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (–)-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (4–7), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC(50) value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils.
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spelling pubmed-65391532019-05-31 New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita Cao, Liang Shehla, Nuzhat Tasneem, Shumaila Cao, Mengru Sheng, Wenbing Jian, Yuqing Li, Bin Peng, Caiyun Choudhary, M. Iqbal Atta-ur-Rahman, Liao, Duan-fang Wang, Wei Molecules Article As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (–)-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (4–7), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC(50) value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils. MDPI 2019-04-28 /pmc/articles/PMC6539153/ /pubmed/31035334 http://dx.doi.org/10.3390/molecules24091664 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cao, Liang
Shehla, Nuzhat
Tasneem, Shumaila
Cao, Mengru
Sheng, Wenbing
Jian, Yuqing
Li, Bin
Peng, Caiyun
Choudhary, M. Iqbal
Atta-ur-Rahman,
Liao, Duan-fang
Wang, Wei
New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita
title New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita
title_full New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita
title_fullStr New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita
title_full_unstemmed New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita
title_short New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita
title_sort new cadinane sesquiterpenes from the stems of kadsura heteroclita
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539153/
https://www.ncbi.nlm.nih.gov/pubmed/31035334
http://dx.doi.org/10.3390/molecules24091664
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