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New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita
As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539153/ https://www.ncbi.nlm.nih.gov/pubmed/31035334 http://dx.doi.org/10.3390/molecules24091664 |
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author | Cao, Liang Shehla, Nuzhat Tasneem, Shumaila Cao, Mengru Sheng, Wenbing Jian, Yuqing Li, Bin Peng, Caiyun Choudhary, M. Iqbal Atta-ur-Rahman, Liao, Duan-fang Wang, Wei |
author_facet | Cao, Liang Shehla, Nuzhat Tasneem, Shumaila Cao, Mengru Sheng, Wenbing Jian, Yuqing Li, Bin Peng, Caiyun Choudhary, M. Iqbal Atta-ur-Rahman, Liao, Duan-fang Wang, Wei |
author_sort | Cao, Liang |
collection | PubMed |
description | As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (–)-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (4–7), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC(50) value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils. |
format | Online Article Text |
id | pubmed-6539153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65391532019-05-31 New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita Cao, Liang Shehla, Nuzhat Tasneem, Shumaila Cao, Mengru Sheng, Wenbing Jian, Yuqing Li, Bin Peng, Caiyun Choudhary, M. Iqbal Atta-ur-Rahman, Liao, Duan-fang Wang, Wei Molecules Article As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (–)-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (4–7), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC(50) value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils. MDPI 2019-04-28 /pmc/articles/PMC6539153/ /pubmed/31035334 http://dx.doi.org/10.3390/molecules24091664 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cao, Liang Shehla, Nuzhat Tasneem, Shumaila Cao, Mengru Sheng, Wenbing Jian, Yuqing Li, Bin Peng, Caiyun Choudhary, M. Iqbal Atta-ur-Rahman, Liao, Duan-fang Wang, Wei New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita |
title | New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita |
title_full | New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita |
title_fullStr | New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita |
title_full_unstemmed | New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita |
title_short | New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita |
title_sort | new cadinane sesquiterpenes from the stems of kadsura heteroclita |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539153/ https://www.ncbi.nlm.nih.gov/pubmed/31035334 http://dx.doi.org/10.3390/molecules24091664 |
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