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Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials
In the last two decades, various nanomaterials have attracted increasing attention in medical science owing to their unique physical and chemical characteristics. Incorporating radionuclides into conventionally used nanomaterials can confer useful additional properties compared to the original mater...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539387/ https://www.ncbi.nlm.nih.gov/pubmed/31083402 http://dx.doi.org/10.3390/ijms20092323 |
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author | Jeon, Jongho |
author_facet | Jeon, Jongho |
author_sort | Jeon, Jongho |
collection | PubMed |
description | In the last two decades, various nanomaterials have attracted increasing attention in medical science owing to their unique physical and chemical characteristics. Incorporating radionuclides into conventionally used nanomaterials can confer useful additional properties compared to the original material. Therefore, various radionuclides have been used to synthesize functional nanomaterials for biomedical applications. In particular, several α- or β-emitter-labeled organic and inorganic nanoparticles have been extensively investigated for efficient and targeted cancer treatment. This article reviews recent progress in cancer therapy using radiolabeled nanomaterials including inorganic, polymeric, and carbon-based materials and liposomes. We first provide an overview of radiolabeling methods for preparing anticancer agents that have been investigated recently in preclinical studies. Next, we discuss the therapeutic applications and effectiveness of α- or β-emitter-incorporated nanomaterials in animal models and the emerging possibilities of these nanomaterials in cancer therapy. |
format | Online Article Text |
id | pubmed-6539387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65393872019-06-04 Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials Jeon, Jongho Int J Mol Sci Review In the last two decades, various nanomaterials have attracted increasing attention in medical science owing to their unique physical and chemical characteristics. Incorporating radionuclides into conventionally used nanomaterials can confer useful additional properties compared to the original material. Therefore, various radionuclides have been used to synthesize functional nanomaterials for biomedical applications. In particular, several α- or β-emitter-labeled organic and inorganic nanoparticles have been extensively investigated for efficient and targeted cancer treatment. This article reviews recent progress in cancer therapy using radiolabeled nanomaterials including inorganic, polymeric, and carbon-based materials and liposomes. We first provide an overview of radiolabeling methods for preparing anticancer agents that have been investigated recently in preclinical studies. Next, we discuss the therapeutic applications and effectiveness of α- or β-emitter-incorporated nanomaterials in animal models and the emerging possibilities of these nanomaterials in cancer therapy. MDPI 2019-05-10 /pmc/articles/PMC6539387/ /pubmed/31083402 http://dx.doi.org/10.3390/ijms20092323 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jeon, Jongho Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials |
title | Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials |
title_full | Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials |
title_fullStr | Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials |
title_full_unstemmed | Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials |
title_short | Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials |
title_sort | review of therapeutic applications of radiolabeled functional nanomaterials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539387/ https://www.ncbi.nlm.nih.gov/pubmed/31083402 http://dx.doi.org/10.3390/ijms20092323 |
work_keys_str_mv | AT jeonjongho reviewoftherapeuticapplicationsofradiolabeledfunctionalnanomaterials |