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Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials

In the last two decades, various nanomaterials have attracted increasing attention in medical science owing to their unique physical and chemical characteristics. Incorporating radionuclides into conventionally used nanomaterials can confer useful additional properties compared to the original mater...

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Autor principal: Jeon, Jongho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539387/
https://www.ncbi.nlm.nih.gov/pubmed/31083402
http://dx.doi.org/10.3390/ijms20092323
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author Jeon, Jongho
author_facet Jeon, Jongho
author_sort Jeon, Jongho
collection PubMed
description In the last two decades, various nanomaterials have attracted increasing attention in medical science owing to their unique physical and chemical characteristics. Incorporating radionuclides into conventionally used nanomaterials can confer useful additional properties compared to the original material. Therefore, various radionuclides have been used to synthesize functional nanomaterials for biomedical applications. In particular, several α- or β-emitter-labeled organic and inorganic nanoparticles have been extensively investigated for efficient and targeted cancer treatment. This article reviews recent progress in cancer therapy using radiolabeled nanomaterials including inorganic, polymeric, and carbon-based materials and liposomes. We first provide an overview of radiolabeling methods for preparing anticancer agents that have been investigated recently in preclinical studies. Next, we discuss the therapeutic applications and effectiveness of α- or β-emitter-incorporated nanomaterials in animal models and the emerging possibilities of these nanomaterials in cancer therapy.
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spelling pubmed-65393872019-06-04 Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials Jeon, Jongho Int J Mol Sci Review In the last two decades, various nanomaterials have attracted increasing attention in medical science owing to their unique physical and chemical characteristics. Incorporating radionuclides into conventionally used nanomaterials can confer useful additional properties compared to the original material. Therefore, various radionuclides have been used to synthesize functional nanomaterials for biomedical applications. In particular, several α- or β-emitter-labeled organic and inorganic nanoparticles have been extensively investigated for efficient and targeted cancer treatment. This article reviews recent progress in cancer therapy using radiolabeled nanomaterials including inorganic, polymeric, and carbon-based materials and liposomes. We first provide an overview of radiolabeling methods for preparing anticancer agents that have been investigated recently in preclinical studies. Next, we discuss the therapeutic applications and effectiveness of α- or β-emitter-incorporated nanomaterials in animal models and the emerging possibilities of these nanomaterials in cancer therapy. MDPI 2019-05-10 /pmc/articles/PMC6539387/ /pubmed/31083402 http://dx.doi.org/10.3390/ijms20092323 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jeon, Jongho
Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials
title Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials
title_full Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials
title_fullStr Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials
title_full_unstemmed Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials
title_short Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials
title_sort review of therapeutic applications of radiolabeled functional nanomaterials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539387/
https://www.ncbi.nlm.nih.gov/pubmed/31083402
http://dx.doi.org/10.3390/ijms20092323
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