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Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent

Poly(methyl methacrylate) (PMMA) bone cements have been widely used in clinical practices. In order to enhance PMMA’s imaging performance to facilitate surgical procedures, a supplementation of radiopaque agent is needed. However, PMMA bone cements are still facing problems of loosening and bacteria...

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Detalles Bibliográficos
Autores principales: Li, Jiaying, Wang, Huan, Guo, Qianping, Zhu, Caihong, Zhu, Xuesong, Han, Fengxuan, Yang, Huilin, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539451/
https://www.ncbi.nlm.nih.gov/pubmed/31027323
http://dx.doi.org/10.3390/ijms20092055
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author Li, Jiaying
Wang, Huan
Guo, Qianping
Zhu, Caihong
Zhu, Xuesong
Han, Fengxuan
Yang, Huilin
Li, Bin
author_facet Li, Jiaying
Wang, Huan
Guo, Qianping
Zhu, Caihong
Zhu, Xuesong
Han, Fengxuan
Yang, Huilin
Li, Bin
author_sort Li, Jiaying
collection PubMed
description Poly(methyl methacrylate) (PMMA) bone cements have been widely used in clinical practices. In order to enhance PMMA’s imaging performance to facilitate surgical procedures, a supplementation of radiopaque agent is needed. However, PMMA bone cements are still facing problems of loosening and bacterial infection. In this study, a multifunctional coating to simultaneously encapsulate drug and prevent the infection of radiopaque agent has been developed. Barium sulfate (BaSO(4)), a common radiopaque agent, is used as a substrate material. We successfully fabricated porous BaSO(4) microparticles, then modified with hexakis-(6-iodo-6-deoxy)-alpha-cyclodextrin (I-CD) and silver (Ag) to obtain porous BaSO(4)@PDA/I-CD/Ag microparticles. The porous nature and presence of PDA coating and I-CD on the surface of microparticles result in efficient loading and release of drugs such as protein. Meanwhile, the radiopacity of BaSO(4)@PDA/I-CD/Ag microparticles is enhanced by this multifunctional coating containing Ba, I and Ag. PMMA bone cements containing BaSO(4)@PDA/I-CD/Ag microparticles show 99% antibacterial rate against both Staphylococcus aureus (S. aureus) and Escherichia Coli (E. coli), yet without apparently affecting its biocompatibility. Together, this multifunctional coating possessing enhanced radiopacity, controlled drug delivery capability and exceptional antibacterial performance, may be a new way to modify radiopaque agents for bone cements.
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spelling pubmed-65394512019-06-04 Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent Li, Jiaying Wang, Huan Guo, Qianping Zhu, Caihong Zhu, Xuesong Han, Fengxuan Yang, Huilin Li, Bin Int J Mol Sci Article Poly(methyl methacrylate) (PMMA) bone cements have been widely used in clinical practices. In order to enhance PMMA’s imaging performance to facilitate surgical procedures, a supplementation of radiopaque agent is needed. However, PMMA bone cements are still facing problems of loosening and bacterial infection. In this study, a multifunctional coating to simultaneously encapsulate drug and prevent the infection of radiopaque agent has been developed. Barium sulfate (BaSO(4)), a common radiopaque agent, is used as a substrate material. We successfully fabricated porous BaSO(4) microparticles, then modified with hexakis-(6-iodo-6-deoxy)-alpha-cyclodextrin (I-CD) and silver (Ag) to obtain porous BaSO(4)@PDA/I-CD/Ag microparticles. The porous nature and presence of PDA coating and I-CD on the surface of microparticles result in efficient loading and release of drugs such as protein. Meanwhile, the radiopacity of BaSO(4)@PDA/I-CD/Ag microparticles is enhanced by this multifunctional coating containing Ba, I and Ag. PMMA bone cements containing BaSO(4)@PDA/I-CD/Ag microparticles show 99% antibacterial rate against both Staphylococcus aureus (S. aureus) and Escherichia Coli (E. coli), yet without apparently affecting its biocompatibility. Together, this multifunctional coating possessing enhanced radiopacity, controlled drug delivery capability and exceptional antibacterial performance, may be a new way to modify radiopaque agents for bone cements. MDPI 2019-04-26 /pmc/articles/PMC6539451/ /pubmed/31027323 http://dx.doi.org/10.3390/ijms20092055 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Jiaying
Wang, Huan
Guo, Qianping
Zhu, Caihong
Zhu, Xuesong
Han, Fengxuan
Yang, Huilin
Li, Bin
Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent
title Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent
title_full Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent
title_fullStr Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent
title_full_unstemmed Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent
title_short Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent
title_sort multifunctional coating to simultaneously encapsulate drug and prevent infection of radiopaque agent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539451/
https://www.ncbi.nlm.nih.gov/pubmed/31027323
http://dx.doi.org/10.3390/ijms20092055
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