Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials

Insulin-resistance is one of the main factors responsible for the onset and progression of Metabolic Syndrome (MetS). Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies. The aim of this revi...

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Detalles Bibliográficos
Autores principales: Russo, Benedetta, Picconi, Fabiana, Malandrucco, Ilaria, Frontoni, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539502/
https://www.ncbi.nlm.nih.gov/pubmed/31027340
http://dx.doi.org/10.3390/ijms20092061
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author Russo, Benedetta
Picconi, Fabiana
Malandrucco, Ilaria
Frontoni, Simona
author_facet Russo, Benedetta
Picconi, Fabiana
Malandrucco, Ilaria
Frontoni, Simona
author_sort Russo, Benedetta
collection PubMed
description Insulin-resistance is one of the main factors responsible for the onset and progression of Metabolic Syndrome (MetS). Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies. The aim of this review is to analyse the data observed in vitro, in vivo and in clinical trials concerning the effects of flavonoids on insulin resistance and to determine the molecular mechanisms with which flavonoids interact with insulin signaling.
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spelling pubmed-65395022019-06-04 Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials Russo, Benedetta Picconi, Fabiana Malandrucco, Ilaria Frontoni, Simona Int J Mol Sci Review Insulin-resistance is one of the main factors responsible for the onset and progression of Metabolic Syndrome (MetS). Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies. The aim of this review is to analyse the data observed in vitro, in vivo and in clinical trials concerning the effects of flavonoids on insulin resistance and to determine the molecular mechanisms with which flavonoids interact with insulin signaling. MDPI 2019-04-26 /pmc/articles/PMC6539502/ /pubmed/31027340 http://dx.doi.org/10.3390/ijms20092061 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Russo, Benedetta
Picconi, Fabiana
Malandrucco, Ilaria
Frontoni, Simona
Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_full Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_fullStr Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_full_unstemmed Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_short Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_sort flavonoids and insulin-resistance: from molecular evidences to clinical trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539502/
https://www.ncbi.nlm.nih.gov/pubmed/31027340
http://dx.doi.org/10.3390/ijms20092061
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