Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells

Tisagenlecleucel is a chimeric antigen receptor–T cell therapy that facilitates the killing of CD19(+) B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab and corticosteroids) on expansion. Data from two...

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Detalles Bibliográficos
Autores principales: Stein, Andrew M., Grupp, Stephan A., Levine, John E., Laetsch, Theodore W., Pulsipher, Michael A., Boyer, Michael W., August, Keith J., Levine, Bruce L., Tomassian, Lori, Shah, Sweta, Leung, Mimi, Huang, Pai‐Hsi, Awasthi, Rakesh, Mueller, Karen Thudium, Wood, Patricia A., June, Carl H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539725/
https://www.ncbi.nlm.nih.gov/pubmed/30848084
http://dx.doi.org/10.1002/psp4.12388

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