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Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring †
Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and/or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In orde...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539756/ https://www.ncbi.nlm.nih.gov/pubmed/31035504 http://dx.doi.org/10.3390/s19091971 |
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author | Otero, Jorge Felis, Ivan Ardid, Miguel Herrero, Alicia |
author_facet | Otero, Jorge Felis, Ivan Ardid, Miguel Herrero, Alicia |
author_sort | Otero, Jorge |
collection | PubMed |
description | Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and/or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In order to maximize the effectiveness of heavy particle treatments, an accurate monitoring system of the deposited dose depending on the energy, beam time, and spot size is necessary. The localized deposition of this energy leads to the generation of a thermoacoustic pulse that can be detected using acoustic technologies. This article presents different experimental and simulation studies of the acoustic localization of thermoacoustic pulses captured with a set of sensors around the sample. In addition, numerical simulations have been done where thermo-acoustic pulses are emitted for the specific case of a proton beam of 100 MeV. |
format | Online Article Text |
id | pubmed-6539756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65397562019-06-04 Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring † Otero, Jorge Felis, Ivan Ardid, Miguel Herrero, Alicia Sensors (Basel) Article Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and/or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In order to maximize the effectiveness of heavy particle treatments, an accurate monitoring system of the deposited dose depending on the energy, beam time, and spot size is necessary. The localized deposition of this energy leads to the generation of a thermoacoustic pulse that can be detected using acoustic technologies. This article presents different experimental and simulation studies of the acoustic localization of thermoacoustic pulses captured with a set of sensors around the sample. In addition, numerical simulations have been done where thermo-acoustic pulses are emitted for the specific case of a proton beam of 100 MeV. MDPI 2019-04-26 /pmc/articles/PMC6539756/ /pubmed/31035504 http://dx.doi.org/10.3390/s19091971 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Otero, Jorge Felis, Ivan Ardid, Miguel Herrero, Alicia Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring † |
title | Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring † |
title_full | Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring † |
title_fullStr | Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring † |
title_full_unstemmed | Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring † |
title_short | Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring † |
title_sort | acoustic localization of bragg peak proton beams for hadrontherapy monitoring † |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539756/ https://www.ncbi.nlm.nih.gov/pubmed/31035504 http://dx.doi.org/10.3390/s19091971 |
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