Cargando…

Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring †

Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and/or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In orde...

Descripción completa

Detalles Bibliográficos
Autores principales: Otero, Jorge, Felis, Ivan, Ardid, Miguel, Herrero, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539756/
https://www.ncbi.nlm.nih.gov/pubmed/31035504
http://dx.doi.org/10.3390/s19091971
_version_ 1783422464020185088
author Otero, Jorge
Felis, Ivan
Ardid, Miguel
Herrero, Alicia
author_facet Otero, Jorge
Felis, Ivan
Ardid, Miguel
Herrero, Alicia
author_sort Otero, Jorge
collection PubMed
description Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and/or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In order to maximize the effectiveness of heavy particle treatments, an accurate monitoring system of the deposited dose depending on the energy, beam time, and spot size is necessary. The localized deposition of this energy leads to the generation of a thermoacoustic pulse that can be detected using acoustic technologies. This article presents different experimental and simulation studies of the acoustic localization of thermoacoustic pulses captured with a set of sensors around the sample. In addition, numerical simulations have been done where thermo-acoustic pulses are emitted for the specific case of a proton beam of 100 MeV.
format Online
Article
Text
id pubmed-6539756
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65397562019-06-04 Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring † Otero, Jorge Felis, Ivan Ardid, Miguel Herrero, Alicia Sensors (Basel) Article Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and/or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In order to maximize the effectiveness of heavy particle treatments, an accurate monitoring system of the deposited dose depending on the energy, beam time, and spot size is necessary. The localized deposition of this energy leads to the generation of a thermoacoustic pulse that can be detected using acoustic technologies. This article presents different experimental and simulation studies of the acoustic localization of thermoacoustic pulses captured with a set of sensors around the sample. In addition, numerical simulations have been done where thermo-acoustic pulses are emitted for the specific case of a proton beam of 100 MeV. MDPI 2019-04-26 /pmc/articles/PMC6539756/ /pubmed/31035504 http://dx.doi.org/10.3390/s19091971 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Otero, Jorge
Felis, Ivan
Ardid, Miguel
Herrero, Alicia
Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring †
title Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring †
title_full Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring †
title_fullStr Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring †
title_full_unstemmed Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring †
title_short Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring †
title_sort acoustic localization of bragg peak proton beams for hadrontherapy monitoring †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539756/
https://www.ncbi.nlm.nih.gov/pubmed/31035504
http://dx.doi.org/10.3390/s19091971
work_keys_str_mv AT oterojorge acousticlocalizationofbraggpeakprotonbeamsforhadrontherapymonitoring
AT felisivan acousticlocalizationofbraggpeakprotonbeamsforhadrontherapymonitoring
AT ardidmiguel acousticlocalizationofbraggpeakprotonbeamsforhadrontherapymonitoring
AT herreroalicia acousticlocalizationofbraggpeakprotonbeamsforhadrontherapymonitoring