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Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease

With the progressive epidemics of obesity, non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in adults and children. The increasing prevalence and incidence of NAFLD with advanced fibrosis is concerning because patients appear to experience higher no...

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Autores principales: El Hadi, Hamza, Di Vincenzo, Angelo, Vettor, Roberto, Rossato, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539803/
https://www.ncbi.nlm.nih.gov/pubmed/31064058
http://dx.doi.org/10.3390/ijms20092215
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author El Hadi, Hamza
Di Vincenzo, Angelo
Vettor, Roberto
Rossato, Marco
author_facet El Hadi, Hamza
Di Vincenzo, Angelo
Vettor, Roberto
Rossato, Marco
author_sort El Hadi, Hamza
collection PubMed
description With the progressive epidemics of obesity, non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in adults and children. The increasing prevalence and incidence of NAFLD with advanced fibrosis is concerning because patients appear to experience higher non-liver-related morbidity and mortality than the general population. Recent clinical evidence suggests that NAFLD is directly associated with an increased risk of cardio-metabolic disorders. This mini review describes briefly the current understanding of the pathogenesis of NAFLD, summarizing the link between NAFLD and cardio-metabolic complications, focusing mainly upon ischemic stroke, type 2 diabetes mellitus (DM), hypertension, chronic kidney disease (CKD) and cardiac arrhythmias. In addition, it describes briefly the current understanding of the pathogenesis of NAFLD.
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spelling pubmed-65398032019-06-04 Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease El Hadi, Hamza Di Vincenzo, Angelo Vettor, Roberto Rossato, Marco Int J Mol Sci Review With the progressive epidemics of obesity, non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in adults and children. The increasing prevalence and incidence of NAFLD with advanced fibrosis is concerning because patients appear to experience higher non-liver-related morbidity and mortality than the general population. Recent clinical evidence suggests that NAFLD is directly associated with an increased risk of cardio-metabolic disorders. This mini review describes briefly the current understanding of the pathogenesis of NAFLD, summarizing the link between NAFLD and cardio-metabolic complications, focusing mainly upon ischemic stroke, type 2 diabetes mellitus (DM), hypertension, chronic kidney disease (CKD) and cardiac arrhythmias. In addition, it describes briefly the current understanding of the pathogenesis of NAFLD. MDPI 2019-05-06 /pmc/articles/PMC6539803/ /pubmed/31064058 http://dx.doi.org/10.3390/ijms20092215 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
El Hadi, Hamza
Di Vincenzo, Angelo
Vettor, Roberto
Rossato, Marco
Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease
title Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease
title_full Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease
title_fullStr Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease
title_full_unstemmed Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease
title_short Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease
title_sort cardio-metabolic disorders in non-alcoholic fatty liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539803/
https://www.ncbi.nlm.nih.gov/pubmed/31064058
http://dx.doi.org/10.3390/ijms20092215
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