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Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination
Background: Immunization of healthcare workers (HCWs) and medical students for the hepatitis B virus (HBV) is a crucial part of the hospital infection control programs. The aim of our study was to evaluate the persistence of anti-HBV specific antibodies in HCWs vaccinated during infancy or adolescen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539932/ https://www.ncbi.nlm.nih.gov/pubmed/31035698 http://dx.doi.org/10.3390/ijerph16091515 |
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author | Coppeta, Luca Pompei, Andrea Balbi, Ottavia De Zordo, Ludovico M. Mormone, Federica Policardo, Sara Lieto, Piergiorgio Pietroiusti, Antonio Magrini, Andrea |
author_facet | Coppeta, Luca Pompei, Andrea Balbi, Ottavia De Zordo, Ludovico M. Mormone, Federica Policardo, Sara Lieto, Piergiorgio Pietroiusti, Antonio Magrini, Andrea |
author_sort | Coppeta, Luca |
collection | PubMed |
description | Background: Immunization of healthcare workers (HCWs) and medical students for the hepatitis B virus (HBV) is a crucial part of the hospital infection control programs. The aim of our study was to evaluate the persistence of anti-HBV specific antibodies in HCWs vaccinated during infancy or adolescence. Methods: Medical records of 734 consecutive subjects born after 1980 (481 females, 65.5% and 253 males, 34.5%) who underwent serological testing for anti-hepatitis B surface antibodies (anti-HBs) were evaluated. Results: A non-protective titer (<10 mUI) was found in 88/734 (12.0%) subjects; 84 (47.8%) of them received a booster dose of anti-hepatitis B vaccine and the anti-HBs titer of 58 subjects was measured 1 month after administration. A protective titer (anti-HBs >10 mIU/mL) was observed in almost 90% of subjects receiving the booster dose. Conclusions: A substantial percentage of HCWs had a non-protective anti-HBs titer at the time of the first employment, especially those vaccinated at birth age. However, the response to the booster dose showed that in these subjects, an anti-HBs titer <10 mIU/mL was due to the physiological decline of antibodies over the years. Therefore, primary immunization in childhood is highly effective and provides lasting immunity against HBV infection. |
format | Online Article Text |
id | pubmed-6539932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65399322019-06-05 Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination Coppeta, Luca Pompei, Andrea Balbi, Ottavia De Zordo, Ludovico M. Mormone, Federica Policardo, Sara Lieto, Piergiorgio Pietroiusti, Antonio Magrini, Andrea Int J Environ Res Public Health Article Background: Immunization of healthcare workers (HCWs) and medical students for the hepatitis B virus (HBV) is a crucial part of the hospital infection control programs. The aim of our study was to evaluate the persistence of anti-HBV specific antibodies in HCWs vaccinated during infancy or adolescence. Methods: Medical records of 734 consecutive subjects born after 1980 (481 females, 65.5% and 253 males, 34.5%) who underwent serological testing for anti-hepatitis B surface antibodies (anti-HBs) were evaluated. Results: A non-protective titer (<10 mUI) was found in 88/734 (12.0%) subjects; 84 (47.8%) of them received a booster dose of anti-hepatitis B vaccine and the anti-HBs titer of 58 subjects was measured 1 month after administration. A protective titer (anti-HBs >10 mIU/mL) was observed in almost 90% of subjects receiving the booster dose. Conclusions: A substantial percentage of HCWs had a non-protective anti-HBs titer at the time of the first employment, especially those vaccinated at birth age. However, the response to the booster dose showed that in these subjects, an anti-HBs titer <10 mIU/mL was due to the physiological decline of antibodies over the years. Therefore, primary immunization in childhood is highly effective and provides lasting immunity against HBV infection. MDPI 2019-04-29 2019-05 /pmc/articles/PMC6539932/ /pubmed/31035698 http://dx.doi.org/10.3390/ijerph16091515 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Coppeta, Luca Pompei, Andrea Balbi, Ottavia De Zordo, Ludovico M. Mormone, Federica Policardo, Sara Lieto, Piergiorgio Pietroiusti, Antonio Magrini, Andrea Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination |
title | Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination |
title_full | Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination |
title_fullStr | Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination |
title_full_unstemmed | Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination |
title_short | Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination |
title_sort | persistence of immunity for hepatitis b virus among heathcare workers and italian medical students 20 years after vaccination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539932/ https://www.ncbi.nlm.nih.gov/pubmed/31035698 http://dx.doi.org/10.3390/ijerph16091515 |
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