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Ion Channels Involved in Tooth Pain

The tooth has an unusual sensory system that converts external stimuli predominantly into pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non-nociceptive neurons. This review summarizes the recent knowledge underlying this paradoxical nociception, with a focus on the...

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Autores principales: Lee, Kihwan, Lee, Byeong-Min, Park, Chul-Kyu, Kim, Yong Ho, Chung, Gehoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539952/
https://www.ncbi.nlm.nih.gov/pubmed/31071917
http://dx.doi.org/10.3390/ijms20092266
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author Lee, Kihwan
Lee, Byeong-Min
Park, Chul-Kyu
Kim, Yong Ho
Chung, Gehoon
author_facet Lee, Kihwan
Lee, Byeong-Min
Park, Chul-Kyu
Kim, Yong Ho
Chung, Gehoon
author_sort Lee, Kihwan
collection PubMed
description The tooth has an unusual sensory system that converts external stimuli predominantly into pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non-nociceptive neurons. This review summarizes the recent knowledge underlying this paradoxical nociception, with a focus on the ion channels involved in tooth pain. The expression of temperature-sensitive ion channels has been extensively investigated because thermal stimulation often evokes tooth pain. However, temperature-sensitive ion channels cannot explain the sudden intense tooth pain evoked by innocuous temperatures or light air puffs, leading to the hydrodynamic theory emphasizing the microfluidic movement within the dentinal tubules for detection by mechanosensitive ion channels. Several mechanosensitive ion channels expressed in dental sensory systems have been suggested as key players in the hydrodynamic theory, and TRPM7, which is abundant in the odontoblasts, and recently discovered PIEZO receptors are promising candidates. Several ligand-gated ion channels and voltage-gated ion channels expressed in dental primary afferent neurons have been discussed in relation to their potential contribution to tooth pain. In addition, in recent years, there has been growing interest in the potential sensory role of odontoblasts; thus, the expression of ion channels in odontoblasts and their potential relation to tooth pain is also reviewed.
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spelling pubmed-65399522019-06-04 Ion Channels Involved in Tooth Pain Lee, Kihwan Lee, Byeong-Min Park, Chul-Kyu Kim, Yong Ho Chung, Gehoon Int J Mol Sci Review The tooth has an unusual sensory system that converts external stimuli predominantly into pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non-nociceptive neurons. This review summarizes the recent knowledge underlying this paradoxical nociception, with a focus on the ion channels involved in tooth pain. The expression of temperature-sensitive ion channels has been extensively investigated because thermal stimulation often evokes tooth pain. However, temperature-sensitive ion channels cannot explain the sudden intense tooth pain evoked by innocuous temperatures or light air puffs, leading to the hydrodynamic theory emphasizing the microfluidic movement within the dentinal tubules for detection by mechanosensitive ion channels. Several mechanosensitive ion channels expressed in dental sensory systems have been suggested as key players in the hydrodynamic theory, and TRPM7, which is abundant in the odontoblasts, and recently discovered PIEZO receptors are promising candidates. Several ligand-gated ion channels and voltage-gated ion channels expressed in dental primary afferent neurons have been discussed in relation to their potential contribution to tooth pain. In addition, in recent years, there has been growing interest in the potential sensory role of odontoblasts; thus, the expression of ion channels in odontoblasts and their potential relation to tooth pain is also reviewed. MDPI 2019-05-08 /pmc/articles/PMC6539952/ /pubmed/31071917 http://dx.doi.org/10.3390/ijms20092266 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Kihwan
Lee, Byeong-Min
Park, Chul-Kyu
Kim, Yong Ho
Chung, Gehoon
Ion Channels Involved in Tooth Pain
title Ion Channels Involved in Tooth Pain
title_full Ion Channels Involved in Tooth Pain
title_fullStr Ion Channels Involved in Tooth Pain
title_full_unstemmed Ion Channels Involved in Tooth Pain
title_short Ion Channels Involved in Tooth Pain
title_sort ion channels involved in tooth pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539952/
https://www.ncbi.nlm.nih.gov/pubmed/31071917
http://dx.doi.org/10.3390/ijms20092266
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