Cargando…
Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
The goal of this study was to investigate Cannabidiol (CBD) hepatotoxicity in 8-week-old male B6C3F(1) mice. Animals were gavaged with either 0, 246, 738, or 2460 mg/kg of CBD (acute toxicity, 24 h) or with daily doses of 0, 61.5, 184.5, or 615 mg/kg for 10 days (sub-acute toxicity). These doses wer...
Autores principales: | Ewing, Laura E., Skinner, Charles M., Quick, Charles M., Kennon-McGill, Stefanie, McGill, Mitchell R., Walker, Larry A., ElSohly, Mahmoud A., Gurley, Bill J., Koturbash, Igor |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539990/ https://www.ncbi.nlm.nih.gov/pubmed/31052254 http://dx.doi.org/10.3390/molecules24091694 |
Ejemplares similares
-
Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
por: Kutanzi, Kristy R., et al.
Publicado: (2020) -
Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
por: Ewing, Laura E., et al.
Publicado: (2019) -
Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F(1) Mice
por: Gurley, Bill J., et al.
Publicado: (2019) -
Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms
por: Kennon-McGill, Stefanie, et al.
Publicado: (2017) -
Absorption and Bioavailability of Novel UltraShear Nanoemulsion of Cannabidiol in Rats
por: ElSohly, Mahmoud A., et al.
Publicado: (2023)