Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine

Engineering aminoacyl-tRNA synthetases (aaRSs) provides access to the ribosomal incorporation of noncanonical amino acids via genetic code expansion. Conventional targeted mutagenesis libraries with 5–7 positions randomized cover only marginal fractions of the vast sequence space formed by up to 30...

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Detalles Bibliográficos
Autores principales: Baumann, Tobias, Hauf, Matthias, Richter, Florian, Albers, Suki, Möglich, Andreas, Ignatova, Zoya, Budisa, Nediljko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539999/
https://www.ncbi.nlm.nih.gov/pubmed/31083552
http://dx.doi.org/10.3390/ijms20092343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539999/
https://www.ncbi.nlm.nih.gov/pubmed/31083552
http://dx.doi.org/10.3390/ijms20092343

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