Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives

A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing (1)H-NMR, (13)C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The res...

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Detalles Bibliográficos
Autores principales: Mabkhot, Yahia N., Algarni, H., Alsayari, Abdulrhman, Bin Muhsinah, Abdullatif, Kheder, Nabila A., Almarhoon, Zainab M., Al-aizari, Faiz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540005/
https://www.ncbi.nlm.nih.gov/pubmed/31035531
http://dx.doi.org/10.3390/molecules24091654
Descripción
Sumario:A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing (1)H-NMR, (13)C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.

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