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A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies
The central pacemakers of circadian timekeeping systems are highly robust yet adaptable, providing the temporal coordination of rhythms in behavior and physiological processes in accordance with the demands imposed by environmental cycles. These features of the central pacemaker are achieved by a mu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540063/ https://www.ncbi.nlm.nih.gov/pubmed/31086044 http://dx.doi.org/10.3390/ijms20092363 |
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author | Hegazi, Sara Lowden, Christopher Rios Garcia, Julian Cheng, Arthur H. Obrietan, Karl Levine, Joel D. Cheng, Hai-Ying Mary |
author_facet | Hegazi, Sara Lowden, Christopher Rios Garcia, Julian Cheng, Arthur H. Obrietan, Karl Levine, Joel D. Cheng, Hai-Ying Mary |
author_sort | Hegazi, Sara |
collection | PubMed |
description | The central pacemakers of circadian timekeeping systems are highly robust yet adaptable, providing the temporal coordination of rhythms in behavior and physiological processes in accordance with the demands imposed by environmental cycles. These features of the central pacemaker are achieved by a multi-oscillator network in which individual cellular oscillators are tightly coupled to the environmental day-night cycle, and to one another via intercellular coupling. In this review, we will summarize the roles of various neurotransmitters and neuropeptides in the regulation of circadian entrainment and synchrony within the mammalian and Drosophila central pacemakers. We will also describe the diverse functions of protein kinases in the relay of input signals to the core oscillator or the direct regulation of the molecular clock machinery. |
format | Online Article Text |
id | pubmed-6540063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65400632019-06-04 A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies Hegazi, Sara Lowden, Christopher Rios Garcia, Julian Cheng, Arthur H. Obrietan, Karl Levine, Joel D. Cheng, Hai-Ying Mary Int J Mol Sci Review The central pacemakers of circadian timekeeping systems are highly robust yet adaptable, providing the temporal coordination of rhythms in behavior and physiological processes in accordance with the demands imposed by environmental cycles. These features of the central pacemaker are achieved by a multi-oscillator network in which individual cellular oscillators are tightly coupled to the environmental day-night cycle, and to one another via intercellular coupling. In this review, we will summarize the roles of various neurotransmitters and neuropeptides in the regulation of circadian entrainment and synchrony within the mammalian and Drosophila central pacemakers. We will also describe the diverse functions of protein kinases in the relay of input signals to the core oscillator or the direct regulation of the molecular clock machinery. MDPI 2019-05-13 /pmc/articles/PMC6540063/ /pubmed/31086044 http://dx.doi.org/10.3390/ijms20092363 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hegazi, Sara Lowden, Christopher Rios Garcia, Julian Cheng, Arthur H. Obrietan, Karl Levine, Joel D. Cheng, Hai-Ying Mary A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies |
title | A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies |
title_full | A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies |
title_fullStr | A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies |
title_full_unstemmed | A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies |
title_short | A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies |
title_sort | symphony of signals: intercellular and intracellular signaling mechanisms underlying circadian timekeeping in mice and flies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540063/ https://www.ncbi.nlm.nih.gov/pubmed/31086044 http://dx.doi.org/10.3390/ijms20092363 |
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