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Sustained delivery of a camptothecin prodrug – CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity

Background and aim: We have synthesized a novel lactone-stabilized camptothecin (CPT) analog named CZ48 and demonstrated its potent anticancer effects via bioconversion to the active CPT in earlier studies. Herein, we aimed to develop, optimize and characterize CZ48 nanosuspensions, for a sustained...

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Detalles Bibliográficos
Autores principales:	Dong, Dong, Hsiao, Cheng-Hui, Giovanella, Beppino C, Wang, Yifei, Chow, Diana SL, Li, Zhijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540077/ https://www.ncbi.nlm.nih.gov/pubmed/31213802 http://dx.doi.org/10.2147/IJN.S196453

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