Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells

Geranylgeraniol (GGOH), a natural isoprenoid found in plants, has anti-inflammatory effects via inhibiting the activation of nuclear factor-kappa B (NFκB). However, its detailed mechanism has not yet been elucidated. Recent studies have revealed that isoprenoids can modulate signaling molecules in i...

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Detalles Bibliográficos
Autores principales: Giriwono, Puspo E., Shirakawa, Hitoshi, Ohsaki, Yusuke, Sato, Shoko, Aoyama, Yukihide, Ho, Hsin-Jung, Goto, Tomoko, Komai, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540148/
https://www.ncbi.nlm.nih.gov/pubmed/31083375
http://dx.doi.org/10.3390/ijms20092320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540148/
https://www.ncbi.nlm.nih.gov/pubmed/31083375
http://dx.doi.org/10.3390/ijms20092320

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