Synthesis, Biological Evaluation and Docking Studies of 13-Epimeric 10-fluoro- and 10-Chloroestra-1,4-dien-3-ones as Potential Aromatase Inhibitors

Fluorination of 13-epimeric estrones and their 17-deoxy counterparts was performed with Selectfluor as the reagent. In acetonitrile or trifluoroacetic acid (TFA), 10β-fluoroestra-1,4-dien-3-ones were formed exclusively. Mechanistic investigations suggest that fluorinations occurred via SET in aceton...

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Detalles Bibliográficos
Autores principales: Jójárt, Rebeka, Traj, Péter, Kovács, Édua, Horváth, Ágnes, Schneider, Gyula, Szécsi, Mihály, Pál, Attila, Paragi, Gábor, Mernyák, Erzsébet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540200/
https://www.ncbi.nlm.nih.gov/pubmed/31072017
http://dx.doi.org/10.3390/molecules24091783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540200/
https://www.ncbi.nlm.nih.gov/pubmed/31072017
http://dx.doi.org/10.3390/molecules24091783

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