Cargando…

Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients

Background and aim: Systemic lupus erythematosus (SLE) is associated with increased risk of cardiovascular disease (CVD). Among many mechanisms, accelerated atherosclerosis, endothelial dysfunction, and hypercoagulability play a main role. Here, we investigate whether inflammatory, serological and c...

Descripción completa

Detalles Bibliográficos
Autores principales: Mercurio, Valentina, Lobasso, Antonio, Barbieri, Letizia, Parrella, Paolo, Ciervo, Deasy, Liccardo, Bianca, Bonaduce, Domenico, Tocchetti, Carlo G., De Paulis, Amato, Rossi, Francesca W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540240/
https://www.ncbi.nlm.nih.gov/pubmed/31052336
http://dx.doi.org/10.3390/ijms20092154
_version_ 1783422575426142208
author Mercurio, Valentina
Lobasso, Antonio
Barbieri, Letizia
Parrella, Paolo
Ciervo, Deasy
Liccardo, Bianca
Bonaduce, Domenico
Tocchetti, Carlo G.
De Paulis, Amato
Rossi, Francesca W.
author_facet Mercurio, Valentina
Lobasso, Antonio
Barbieri, Letizia
Parrella, Paolo
Ciervo, Deasy
Liccardo, Bianca
Bonaduce, Domenico
Tocchetti, Carlo G.
De Paulis, Amato
Rossi, Francesca W.
author_sort Mercurio, Valentina
collection PubMed
description Background and aim: Systemic lupus erythematosus (SLE) is associated with increased risk of cardiovascular disease (CVD). Among many mechanisms, accelerated atherosclerosis, endothelial dysfunction, and hypercoagulability play a main role. Here, we investigate whether inflammatory, serological and clinical markers of SLE determine and correlate with arterial stiffness in SLE patients. Materials and methods: Routine blood samples, inflammatory mediators, specific antibodies, and 24 h proteinuria were measured in 43 SLE patients and 43 age and sex-matched controls using routine laboratory assays. We also assessed arterial stiffness by measuring radial artery applanation tonometry-derived augmentation index (AI), normalized AI (AIx@75), aortic pulse pressure, central systolic, diastolic and peripheral blood pressure. Results: SLE patients showed a significantly greater arterial stiffness vs. controls, as demonstrated by the significantly higher AIx@75 and aortic pulse pressure. Interestingly, regression analysis showed that age, systolic pulse pressure, inflammatory markers (erythrocyte sedimentation rate and C-reactive protein), daily dose of glucocorticoids, and cumulative organ damage positively correlated with arterial stiffness. Conclusions: SLE patients show increased arterial stiffness which correlates with markers of inflammation, that is involved in early alterations in arterial walls. Applanation tonometry can be used to screen SLE patients for subclinical vascular damage to implement prevention strategies for CVD.
format Online
Article
Text
id pubmed-6540240
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65402402019-06-04 Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients Mercurio, Valentina Lobasso, Antonio Barbieri, Letizia Parrella, Paolo Ciervo, Deasy Liccardo, Bianca Bonaduce, Domenico Tocchetti, Carlo G. De Paulis, Amato Rossi, Francesca W. Int J Mol Sci Article Background and aim: Systemic lupus erythematosus (SLE) is associated with increased risk of cardiovascular disease (CVD). Among many mechanisms, accelerated atherosclerosis, endothelial dysfunction, and hypercoagulability play a main role. Here, we investigate whether inflammatory, serological and clinical markers of SLE determine and correlate with arterial stiffness in SLE patients. Materials and methods: Routine blood samples, inflammatory mediators, specific antibodies, and 24 h proteinuria were measured in 43 SLE patients and 43 age and sex-matched controls using routine laboratory assays. We also assessed arterial stiffness by measuring radial artery applanation tonometry-derived augmentation index (AI), normalized AI (AIx@75), aortic pulse pressure, central systolic, diastolic and peripheral blood pressure. Results: SLE patients showed a significantly greater arterial stiffness vs. controls, as demonstrated by the significantly higher AIx@75 and aortic pulse pressure. Interestingly, regression analysis showed that age, systolic pulse pressure, inflammatory markers (erythrocyte sedimentation rate and C-reactive protein), daily dose of glucocorticoids, and cumulative organ damage positively correlated with arterial stiffness. Conclusions: SLE patients show increased arterial stiffness which correlates with markers of inflammation, that is involved in early alterations in arterial walls. Applanation tonometry can be used to screen SLE patients for subclinical vascular damage to implement prevention strategies for CVD. MDPI 2019-04-30 /pmc/articles/PMC6540240/ /pubmed/31052336 http://dx.doi.org/10.3390/ijms20092154 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mercurio, Valentina
Lobasso, Antonio
Barbieri, Letizia
Parrella, Paolo
Ciervo, Deasy
Liccardo, Bianca
Bonaduce, Domenico
Tocchetti, Carlo G.
De Paulis, Amato
Rossi, Francesca W.
Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients
title Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients
title_full Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients
title_fullStr Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients
title_full_unstemmed Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients
title_short Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients
title_sort inflammatory, serological and vascular determinants of cardiovascular disease in systemic lupus erythematosus patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540240/
https://www.ncbi.nlm.nih.gov/pubmed/31052336
http://dx.doi.org/10.3390/ijms20092154
work_keys_str_mv AT mercuriovalentina inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT lobassoantonio inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT barbieriletizia inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT parrellapaolo inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT ciervodeasy inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT liccardobianca inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT bonaducedomenico inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT tocchetticarlog inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT depaulisamato inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients
AT rossifrancescaw inflammatoryserologicalandvasculardeterminantsofcardiovasculardiseaseinsystemiclupuserythematosuspatients