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Design of an Optical Probe to Monitor Vaginal Hemodynamics during Sexual Arousal

An optical probe was developed to measure the change of oxy-hemoglobin (OHb), deoxy- hemoglobin (RHb), and total hemoglobin (THb) along with temperature from the vaginal wall of female rats. Apomorphine (APO, 80 μg/kg) was administered to elicit sexual arousal in female Sprague Dawley rats (SD, 180–...

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Autores principales: Jeong, Hyeryun, Seong, Myeongsu, Lee, Hyun-Suk, Park, Kwangsung, Moon, Sucbei, Kim, Jae Gwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540249/
https://www.ncbi.nlm.nih.gov/pubmed/31071987
http://dx.doi.org/10.3390/s19092129
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author Jeong, Hyeryun
Seong, Myeongsu
Lee, Hyun-Suk
Park, Kwangsung
Moon, Sucbei
Kim, Jae Gwan
author_facet Jeong, Hyeryun
Seong, Myeongsu
Lee, Hyun-Suk
Park, Kwangsung
Moon, Sucbei
Kim, Jae Gwan
author_sort Jeong, Hyeryun
collection PubMed
description An optical probe was developed to measure the change of oxy-hemoglobin (OHb), deoxy- hemoglobin (RHb), and total hemoglobin (THb) along with temperature from the vaginal wall of female rats. Apomorphine (APO, 80 μg/kg) was administered to elicit sexual arousal in female Sprague Dawley rats (SD, 180–200 g). The behavior changes caused by APO administration were checked before monitoring vaginal responses. The changes of oxy-, deoxy-, and total hemoglobin concentration and the temperature from the vaginal wall were monitored before, during, and after APO administration. Animals were under anesthesia during the measurement. After APO administration, the concentration of OHb (55 ± 29 μM/DPF), RHb (33 ± 25 μM/DPF), and THb (83 ± 59 μM/DPF) in the vaginal wall increased in a few min, while saline administration did not cause any significant change. In case of the vaginal temperature change, APO decreased the temperature slightly in the vaginal wall while saline administration did not show any temperature change in the vaginal wall. As the outcomes demonstrated, the developed probe can detect hemodynamic and temperature variation in the vaginal wall. The hemodynamic information acquired by the probe can be utilized to establish an objective and accurate standard of female sexual disorders.
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spelling pubmed-65402492019-06-04 Design of an Optical Probe to Monitor Vaginal Hemodynamics during Sexual Arousal Jeong, Hyeryun Seong, Myeongsu Lee, Hyun-Suk Park, Kwangsung Moon, Sucbei Kim, Jae Gwan Sensors (Basel) Article An optical probe was developed to measure the change of oxy-hemoglobin (OHb), deoxy- hemoglobin (RHb), and total hemoglobin (THb) along with temperature from the vaginal wall of female rats. Apomorphine (APO, 80 μg/kg) was administered to elicit sexual arousal in female Sprague Dawley rats (SD, 180–200 g). The behavior changes caused by APO administration were checked before monitoring vaginal responses. The changes of oxy-, deoxy-, and total hemoglobin concentration and the temperature from the vaginal wall were monitored before, during, and after APO administration. Animals were under anesthesia during the measurement. After APO administration, the concentration of OHb (55 ± 29 μM/DPF), RHb (33 ± 25 μM/DPF), and THb (83 ± 59 μM/DPF) in the vaginal wall increased in a few min, while saline administration did not cause any significant change. In case of the vaginal temperature change, APO decreased the temperature slightly in the vaginal wall while saline administration did not show any temperature change in the vaginal wall. As the outcomes demonstrated, the developed probe can detect hemodynamic and temperature variation in the vaginal wall. The hemodynamic information acquired by the probe can be utilized to establish an objective and accurate standard of female sexual disorders. MDPI 2019-05-08 /pmc/articles/PMC6540249/ /pubmed/31071987 http://dx.doi.org/10.3390/s19092129 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jeong, Hyeryun
Seong, Myeongsu
Lee, Hyun-Suk
Park, Kwangsung
Moon, Sucbei
Kim, Jae Gwan
Design of an Optical Probe to Monitor Vaginal Hemodynamics during Sexual Arousal
title Design of an Optical Probe to Monitor Vaginal Hemodynamics during Sexual Arousal
title_full Design of an Optical Probe to Monitor Vaginal Hemodynamics during Sexual Arousal
title_fullStr Design of an Optical Probe to Monitor Vaginal Hemodynamics during Sexual Arousal
title_full_unstemmed Design of an Optical Probe to Monitor Vaginal Hemodynamics during Sexual Arousal
title_short Design of an Optical Probe to Monitor Vaginal Hemodynamics during Sexual Arousal
title_sort design of an optical probe to monitor vaginal hemodynamics during sexual arousal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540249/
https://www.ncbi.nlm.nih.gov/pubmed/31071987
http://dx.doi.org/10.3390/s19092129
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