Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and carcinogenesis. In previous work, we established that PLK4 is overexpressed in...

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Detalles Bibliográficos
Autores principales: Suri, Amreena, Bailey, Anders W., Tavares, Maurício T., Gunosewoyo, Hendra, Dyer, Connor P., Grupenmacher, Alex T., Piper, David R., Horton, Robert A., Tomita, Tadanori, Kozikowski, Alan P., Roy, Saktimayee M., Sredni, Simone T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540285/
https://www.ncbi.nlm.nih.gov/pubmed/31035676
http://dx.doi.org/10.3390/ijms20092112

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