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Active PZT Composite Microfluidic Channel for Bioparticle Manipulation

The concept of active microchannel for precise manipulation of particles in biomedicine is reported in this paper. A novel vibration-assisted thermal imprint method is proposed for effective formation of a microchannel network in the nanocomposite piezo polymer layer. In this method, bulk acoustic w...

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Autores principales: Janusas, Tomas, Pilkauskas, Kestutis, Janusas, Giedrius, Palevicius, Arvydas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540313/
https://www.ncbi.nlm.nih.gov/pubmed/31035737
http://dx.doi.org/10.3390/s19092020
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author Janusas, Tomas
Pilkauskas, Kestutis
Janusas, Giedrius
Palevicius, Arvydas
author_facet Janusas, Tomas
Pilkauskas, Kestutis
Janusas, Giedrius
Palevicius, Arvydas
author_sort Janusas, Tomas
collection PubMed
description The concept of active microchannel for precise manipulation of particles in biomedicine is reported in this paper. A novel vibration-assisted thermal imprint method is proposed for effective formation of a microchannel network in the nanocomposite piezo polymer layer. In this method, bulk acoustic waves of different wavelengths excited in an imprinted microstructure enable it to function in trapping–patterning, valve, or free particle passing modes. Acoustic waves are excited using a special pattern of electrodes formed on its top surface and a single electric ground electrode formed on the bottom surface. To develop the microchannel, we first started with lead zirconate titanate (PZT) nanopowder [Pb (Zr(x), Ti(1−x)) O(3)] synthesis. The PZT was further mixed with three different binding materials—polyvinyl butyral (PVB), poly(methyl methacrylate) (PMMA), and polystyrene (PS)—in benzyl alcohol to prepare a screen-printing paste. Then, using conventional screen printing techniques, three types of PZT coatings on copper foil substrates were obtained. To improve the voltage characteristics, the coatings were polarized. Their structural and chemical composition was analyzed using scanning electron microscope (SEM), while the mechanical and electrical characteristics were determined using the COMSOL Multiphysics model with experimentally obtained parameters of periodic response of the layered copper foil structure. The hydrophobic properties of the PZT composite were analyzed by measuring the contact angle between the distilled water drop and the three different polymer composites: PZT with PVB, PZT with PMMA, and PZT with PS. Finally, the behavior of the microchannel formed in the nanocomposite piezo polymer was simulated by applying electrical excitation signal on the pattern of electrodes and then analyzed experimentally using holographic interferometry. Wave-shaped vibration forms of the microchannel were obtained, thereby enabling particle manipulation.
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spelling pubmed-65403132019-06-04 Active PZT Composite Microfluidic Channel for Bioparticle Manipulation Janusas, Tomas Pilkauskas, Kestutis Janusas, Giedrius Palevicius, Arvydas Sensors (Basel) Article The concept of active microchannel for precise manipulation of particles in biomedicine is reported in this paper. A novel vibration-assisted thermal imprint method is proposed for effective formation of a microchannel network in the nanocomposite piezo polymer layer. In this method, bulk acoustic waves of different wavelengths excited in an imprinted microstructure enable it to function in trapping–patterning, valve, or free particle passing modes. Acoustic waves are excited using a special pattern of electrodes formed on its top surface and a single electric ground electrode formed on the bottom surface. To develop the microchannel, we first started with lead zirconate titanate (PZT) nanopowder [Pb (Zr(x), Ti(1−x)) O(3)] synthesis. The PZT was further mixed with three different binding materials—polyvinyl butyral (PVB), poly(methyl methacrylate) (PMMA), and polystyrene (PS)—in benzyl alcohol to prepare a screen-printing paste. Then, using conventional screen printing techniques, three types of PZT coatings on copper foil substrates were obtained. To improve the voltage characteristics, the coatings were polarized. Their structural and chemical composition was analyzed using scanning electron microscope (SEM), while the mechanical and electrical characteristics were determined using the COMSOL Multiphysics model with experimentally obtained parameters of periodic response of the layered copper foil structure. The hydrophobic properties of the PZT composite were analyzed by measuring the contact angle between the distilled water drop and the three different polymer composites: PZT with PVB, PZT with PMMA, and PZT with PS. Finally, the behavior of the microchannel formed in the nanocomposite piezo polymer was simulated by applying electrical excitation signal on the pattern of electrodes and then analyzed experimentally using holographic interferometry. Wave-shaped vibration forms of the microchannel were obtained, thereby enabling particle manipulation. MDPI 2019-04-29 /pmc/articles/PMC6540313/ /pubmed/31035737 http://dx.doi.org/10.3390/s19092020 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Janusas, Tomas
Pilkauskas, Kestutis
Janusas, Giedrius
Palevicius, Arvydas
Active PZT Composite Microfluidic Channel for Bioparticle Manipulation
title Active PZT Composite Microfluidic Channel for Bioparticle Manipulation
title_full Active PZT Composite Microfluidic Channel for Bioparticle Manipulation
title_fullStr Active PZT Composite Microfluidic Channel for Bioparticle Manipulation
title_full_unstemmed Active PZT Composite Microfluidic Channel for Bioparticle Manipulation
title_short Active PZT Composite Microfluidic Channel for Bioparticle Manipulation
title_sort active pzt composite microfluidic channel for bioparticle manipulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540313/
https://www.ncbi.nlm.nih.gov/pubmed/31035737
http://dx.doi.org/10.3390/s19092020
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