Novel imidazo[1,2-a]pyridine inhibits AKT/mTOR pathway and induces cell cycle arrest and apoptosis in melanoma and cervical cancer cells

The present study aimed to investigate the anti-cancer activity of imidazo[1,2-a]pyridine 5–7 in the A375 and WM115 melanoma and HeLa cervical cancer cell lines. The viability of cancer cells was analyzed by the MTT assay. Apoptosis was quantified by flow cytometry following staining of the cells wi...

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Detalles Bibliográficos
Autores principales: Aliwaini, Saeb, Awadallah, Adel M., Morjan, Rami Y., Ghunaim, Mariam, Alqaddi, Hala, Abuhamad, Asmaa Y., Awadallah, Enas A., Abughefra, Yasmin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540349/
https://www.ncbi.nlm.nih.gov/pubmed/31289560
http://dx.doi.org/10.3892/ol.2019.10341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540349/
https://www.ncbi.nlm.nih.gov/pubmed/31289560
http://dx.doi.org/10.3892/ol.2019.10341

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