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Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer
Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540497/ https://www.ncbi.nlm.nih.gov/pubmed/31289520 http://dx.doi.org/10.3892/ol.2019.10349 |
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author | Ahmed, Kanwal Zaidi, Syed Faisal Cui, Zheng-Guo Zhou, Dejun Saeed, Sheikh Abdul Inadera, Hidekuni |
author_facet | Ahmed, Kanwal Zaidi, Syed Faisal Cui, Zheng-Guo Zhou, Dejun Saeed, Sheikh Abdul Inadera, Hidekuni |
author_sort | Ahmed, Kanwal |
collection | PubMed |
description | Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fruits and vegetables have a significantly reduced incidence rate of CRC. This chemo-preventive effect is primarily associated with the presence of phytochemicals in the dietary components. Plant-derived chemical agents act as a prominent source of novel compounds for drug discovery. Phytochemicals have been the focus of an increasing number of studies due to their ability to modulate carcinogenic processes through the alteration of multiple cancer cell survival pathways. Despite promising results from experimental studies, only a limited number of phytochemicals have entered into clinical trials. The purpose of the current review is to compile previously published pre-clinical and clinical evidence of phytochemicals in cases of CRC. A PubMed, Google Scholar and Science Direct search was performed for relevant articles published between 2008–2018 using the following key terms: ‘Phytochemicals with colorectal cancers’, ‘apoptosis’, ‘cell cycle’, ‘reactive oxygen species’ and ‘clinical anticancer activities’. The present review may aid in identifying the most investigated phytochemicals in CRC cells, and due to the limited number of studies that make it from the laboratory bench to clinical trial stage, may provide a novel foundation for future research. |
format | Online Article Text |
id | pubmed-6540497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-65404972019-07-09 Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer Ahmed, Kanwal Zaidi, Syed Faisal Cui, Zheng-Guo Zhou, Dejun Saeed, Sheikh Abdul Inadera, Hidekuni Oncol Lett Review Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fruits and vegetables have a significantly reduced incidence rate of CRC. This chemo-preventive effect is primarily associated with the presence of phytochemicals in the dietary components. Plant-derived chemical agents act as a prominent source of novel compounds for drug discovery. Phytochemicals have been the focus of an increasing number of studies due to their ability to modulate carcinogenic processes through the alteration of multiple cancer cell survival pathways. Despite promising results from experimental studies, only a limited number of phytochemicals have entered into clinical trials. The purpose of the current review is to compile previously published pre-clinical and clinical evidence of phytochemicals in cases of CRC. A PubMed, Google Scholar and Science Direct search was performed for relevant articles published between 2008–2018 using the following key terms: ‘Phytochemicals with colorectal cancers’, ‘apoptosis’, ‘cell cycle’, ‘reactive oxygen species’ and ‘clinical anticancer activities’. The present review may aid in identifying the most investigated phytochemicals in CRC cells, and due to the limited number of studies that make it from the laboratory bench to clinical trial stage, may provide a novel foundation for future research. D.A. Spandidos 2019-07 2019-05-13 /pmc/articles/PMC6540497/ /pubmed/31289520 http://dx.doi.org/10.3892/ol.2019.10349 Text en Copyright: © Ahmed et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Ahmed, Kanwal Zaidi, Syed Faisal Cui, Zheng-Guo Zhou, Dejun Saeed, Sheikh Abdul Inadera, Hidekuni Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer |
title | Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer |
title_full | Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer |
title_fullStr | Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer |
title_full_unstemmed | Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer |
title_short | Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer |
title_sort | potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540497/ https://www.ncbi.nlm.nih.gov/pubmed/31289520 http://dx.doi.org/10.3892/ol.2019.10349 |
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