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The TGFβ-miR-499a-SHKBP1 pathway induces resistance to EGFR inhibitors in osteosarcoma cancer stem cell-like cells

BACKGROUND/AIMS: A novel paradigm in tumor biology suggests that osteosarcoma (OS) chemo-resistance is driven by osteosarcoma stem cell-like cells (OSCs). As the sensitivity of only a few tumors to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) can be explained by the pres...

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Detalles Bibliográficos
Autores principales:	Wang, Tian, Wang, Dexing, Zhang, Lian, Yang, Ping, Wang, Jing, Liu, Qi, Yan, Fei, Lin, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540516/ https://www.ncbi.nlm.nih.gov/pubmed/31138318 http://dx.doi.org/10.1186/s13046-019-1195-y

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