Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)

The human mononuclear phagocytes system consists of dendritic cells (DCs), monocytes, and macrophages having different functions in bridging innate and adaptive immunity. Among the heterogeneous population of monocytes the cell surface marker slan (6-sulfo LacNAc) identifies a specific subset of hum...

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Autores principales: Ahmad, Fareed, Döbel, Thomas, Schmitz, Marc, Schäkel, Knut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540605/
https://www.ncbi.nlm.nih.gov/pubmed/31191513
http://dx.doi.org/10.3389/fimmu.2019.00948
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author Ahmad, Fareed
Döbel, Thomas
Schmitz, Marc
Schäkel, Knut
author_facet Ahmad, Fareed
Döbel, Thomas
Schmitz, Marc
Schäkel, Knut
author_sort Ahmad, Fareed
collection PubMed
description The human mononuclear phagocytes system consists of dendritic cells (DCs), monocytes, and macrophages having different functions in bridging innate and adaptive immunity. Among the heterogeneous population of monocytes the cell surface marker slan (6-sulfo LacNAc) identifies a specific subset of human CD14(−) CD16(+) non-classical monocytes, called slan(+) monocytes (slanMo). In this review we discuss the identity and functions of slanMo, their contributions to immune surveillance by pro-inflammatory cytokine production, and cross talk with T cells and NK cells. We also consider the role of slanMo in the regulation of chronic inflammatory diseases and cancer. Finally, we highlight unresolved questions that should be the focus of future research.
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spelling pubmed-65406052019-06-12 Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo) Ahmad, Fareed Döbel, Thomas Schmitz, Marc Schäkel, Knut Front Immunol Immunology The human mononuclear phagocytes system consists of dendritic cells (DCs), monocytes, and macrophages having different functions in bridging innate and adaptive immunity. Among the heterogeneous population of monocytes the cell surface marker slan (6-sulfo LacNAc) identifies a specific subset of human CD14(−) CD16(+) non-classical monocytes, called slan(+) monocytes (slanMo). In this review we discuss the identity and functions of slanMo, their contributions to immune surveillance by pro-inflammatory cytokine production, and cross talk with T cells and NK cells. We also consider the role of slanMo in the regulation of chronic inflammatory diseases and cancer. Finally, we highlight unresolved questions that should be the focus of future research. Frontiers Media S.A. 2019-05-22 /pmc/articles/PMC6540605/ /pubmed/31191513 http://dx.doi.org/10.3389/fimmu.2019.00948 Text en Copyright © 2019 Ahmad, Döbel, Schmitz and Schäkel. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ahmad, Fareed
Döbel, Thomas
Schmitz, Marc
Schäkel, Knut
Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)
title Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)
title_full Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)
title_fullStr Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)
title_full_unstemmed Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)
title_short Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)
title_sort current concepts on 6-sulfo lacnac expressing monocytes (slanmo)
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540605/
https://www.ncbi.nlm.nih.gov/pubmed/31191513
http://dx.doi.org/10.3389/fimmu.2019.00948
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