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Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis
BACKGROUND: Venous thromboembolism (VT) is a leading cause of maternal mortality and morbidity worldwide. Catheter-directed thrombolysis (CDT) is an effective and safe treatment modality for VT patients. However, the long-term outcome of CDT in pregnancy-related venous thrombosis are unclear. The ai...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540639/ https://www.ncbi.nlm.nih.gov/pubmed/31110168 http://dx.doi.org/10.12659/MSM.914592 |
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author | Du, Xiaolong Zhuang, Hao Hong, Lei Zhang, Yeqing Li, Chenglong Qian, Aimin Sang, Hongfei Li, Xiaoqiang |
author_facet | Du, Xiaolong Zhuang, Hao Hong, Lei Zhang, Yeqing Li, Chenglong Qian, Aimin Sang, Hongfei Li, Xiaoqiang |
author_sort | Du, Xiaolong |
collection | PubMed |
description | BACKGROUND: Venous thromboembolism (VT) is a leading cause of maternal mortality and morbidity worldwide. Catheter-directed thrombolysis (CDT) is an effective and safe treatment modality for VT patients. However, the long-term outcome of CDT in pregnancy-related venous thrombosis are unclear. The aim of this study was to assess long-term results of pregnancy-related VT patients. MATERIAL/METHODS: We reviewed 41 pregnancy-related deep venous thrombosis (DVT) patients who underwent CDT from February 2008 to May 2015. Clinical data, including demographic variables, disease location, vascular risk factors, treatment regimen, interventional procedure and complications, were collected retrospectively. Clinical and color-duplex ultrasonography were performed to monitor venous patency during follow-up. Post-thrombotic syndrome (PTS) was assessed with the Villalta scale and quality of life (QOL) was evaluated by the VEINES-QOL/Sym questionnaire. RESULTS: Twenty-three patients underwent spontaneous abortion or induced abortion within 3 months before DVT, and 18 patients had DVT during the first 3 months after delivery. Technical success was achieved in all patients. Grade III (complete) lysis was obtained in 15 patients and grade II (partial) lysis was obtained in 21 patients. The follow-up period was 3 years. Twenty-eight patients had venous patency at 3-year follow-up; 36.6% of patients developed mild or moderate PTS (Villalta score 5–14) and 4.8% with severe PTS (Villalta score ≥15). VEINES-QOL/Sym scores were 55.24±7.35 and 53.25±6.65, respectively. CONCLUSIONS: Catheter-directed thrombolysis is a reliable and safe treatment modality for postnatal or abortion patients with DVT. CDT can reduce the incidence rate of PTS and increase the quality of life. |
format | Online Article Text |
id | pubmed-6540639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65406392019-06-12 Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis Du, Xiaolong Zhuang, Hao Hong, Lei Zhang, Yeqing Li, Chenglong Qian, Aimin Sang, Hongfei Li, Xiaoqiang Med Sci Monit Clinical Research BACKGROUND: Venous thromboembolism (VT) is a leading cause of maternal mortality and morbidity worldwide. Catheter-directed thrombolysis (CDT) is an effective and safe treatment modality for VT patients. However, the long-term outcome of CDT in pregnancy-related venous thrombosis are unclear. The aim of this study was to assess long-term results of pregnancy-related VT patients. MATERIAL/METHODS: We reviewed 41 pregnancy-related deep venous thrombosis (DVT) patients who underwent CDT from February 2008 to May 2015. Clinical data, including demographic variables, disease location, vascular risk factors, treatment regimen, interventional procedure and complications, were collected retrospectively. Clinical and color-duplex ultrasonography were performed to monitor venous patency during follow-up. Post-thrombotic syndrome (PTS) was assessed with the Villalta scale and quality of life (QOL) was evaluated by the VEINES-QOL/Sym questionnaire. RESULTS: Twenty-three patients underwent spontaneous abortion or induced abortion within 3 months before DVT, and 18 patients had DVT during the first 3 months after delivery. Technical success was achieved in all patients. Grade III (complete) lysis was obtained in 15 patients and grade II (partial) lysis was obtained in 21 patients. The follow-up period was 3 years. Twenty-eight patients had venous patency at 3-year follow-up; 36.6% of patients developed mild or moderate PTS (Villalta score 5–14) and 4.8% with severe PTS (Villalta score ≥15). VEINES-QOL/Sym scores were 55.24±7.35 and 53.25±6.65, respectively. CONCLUSIONS: Catheter-directed thrombolysis is a reliable and safe treatment modality for postnatal or abortion patients with DVT. CDT can reduce the incidence rate of PTS and increase the quality of life. International Scientific Literature, Inc. 2019-05-21 /pmc/articles/PMC6540639/ /pubmed/31110168 http://dx.doi.org/10.12659/MSM.914592 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Du, Xiaolong Zhuang, Hao Hong, Lei Zhang, Yeqing Li, Chenglong Qian, Aimin Sang, Hongfei Li, Xiaoqiang Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis |
title | Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis |
title_full | Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis |
title_fullStr | Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis |
title_full_unstemmed | Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis |
title_short | Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis |
title_sort | long-term outcome of catheter-directed thrombolysis in pregnancy-related venous thrombosis |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540639/ https://www.ncbi.nlm.nih.gov/pubmed/31110168 http://dx.doi.org/10.12659/MSM.914592 |
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