Cargando…

Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis

BACKGROUND: Venous thromboembolism (VT) is a leading cause of maternal mortality and morbidity worldwide. Catheter-directed thrombolysis (CDT) is an effective and safe treatment modality for VT patients. However, the long-term outcome of CDT in pregnancy-related venous thrombosis are unclear. The ai...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Xiaolong, Zhuang, Hao, Hong, Lei, Zhang, Yeqing, Li, Chenglong, Qian, Aimin, Sang, Hongfei, Li, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540639/
https://www.ncbi.nlm.nih.gov/pubmed/31110168
http://dx.doi.org/10.12659/MSM.914592
_version_ 1783422663068221440
author Du, Xiaolong
Zhuang, Hao
Hong, Lei
Zhang, Yeqing
Li, Chenglong
Qian, Aimin
Sang, Hongfei
Li, Xiaoqiang
author_facet Du, Xiaolong
Zhuang, Hao
Hong, Lei
Zhang, Yeqing
Li, Chenglong
Qian, Aimin
Sang, Hongfei
Li, Xiaoqiang
author_sort Du, Xiaolong
collection PubMed
description BACKGROUND: Venous thromboembolism (VT) is a leading cause of maternal mortality and morbidity worldwide. Catheter-directed thrombolysis (CDT) is an effective and safe treatment modality for VT patients. However, the long-term outcome of CDT in pregnancy-related venous thrombosis are unclear. The aim of this study was to assess long-term results of pregnancy-related VT patients. MATERIAL/METHODS: We reviewed 41 pregnancy-related deep venous thrombosis (DVT) patients who underwent CDT from February 2008 to May 2015. Clinical data, including demographic variables, disease location, vascular risk factors, treatment regimen, interventional procedure and complications, were collected retrospectively. Clinical and color-duplex ultrasonography were performed to monitor venous patency during follow-up. Post-thrombotic syndrome (PTS) was assessed with the Villalta scale and quality of life (QOL) was evaluated by the VEINES-QOL/Sym questionnaire. RESULTS: Twenty-three patients underwent spontaneous abortion or induced abortion within 3 months before DVT, and 18 patients had DVT during the first 3 months after delivery. Technical success was achieved in all patients. Grade III (complete) lysis was obtained in 15 patients and grade II (partial) lysis was obtained in 21 patients. The follow-up period was 3 years. Twenty-eight patients had venous patency at 3-year follow-up; 36.6% of patients developed mild or moderate PTS (Villalta score 5–14) and 4.8% with severe PTS (Villalta score ≥15). VEINES-QOL/Sym scores were 55.24±7.35 and 53.25±6.65, respectively. CONCLUSIONS: Catheter-directed thrombolysis is a reliable and safe treatment modality for postnatal or abortion patients with DVT. CDT can reduce the incidence rate of PTS and increase the quality of life.
format Online
Article
Text
id pubmed-6540639
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-65406392019-06-12 Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis Du, Xiaolong Zhuang, Hao Hong, Lei Zhang, Yeqing Li, Chenglong Qian, Aimin Sang, Hongfei Li, Xiaoqiang Med Sci Monit Clinical Research BACKGROUND: Venous thromboembolism (VT) is a leading cause of maternal mortality and morbidity worldwide. Catheter-directed thrombolysis (CDT) is an effective and safe treatment modality for VT patients. However, the long-term outcome of CDT in pregnancy-related venous thrombosis are unclear. The aim of this study was to assess long-term results of pregnancy-related VT patients. MATERIAL/METHODS: We reviewed 41 pregnancy-related deep venous thrombosis (DVT) patients who underwent CDT from February 2008 to May 2015. Clinical data, including demographic variables, disease location, vascular risk factors, treatment regimen, interventional procedure and complications, were collected retrospectively. Clinical and color-duplex ultrasonography were performed to monitor venous patency during follow-up. Post-thrombotic syndrome (PTS) was assessed with the Villalta scale and quality of life (QOL) was evaluated by the VEINES-QOL/Sym questionnaire. RESULTS: Twenty-three patients underwent spontaneous abortion or induced abortion within 3 months before DVT, and 18 patients had DVT during the first 3 months after delivery. Technical success was achieved in all patients. Grade III (complete) lysis was obtained in 15 patients and grade II (partial) lysis was obtained in 21 patients. The follow-up period was 3 years. Twenty-eight patients had venous patency at 3-year follow-up; 36.6% of patients developed mild or moderate PTS (Villalta score 5–14) and 4.8% with severe PTS (Villalta score ≥15). VEINES-QOL/Sym scores were 55.24±7.35 and 53.25±6.65, respectively. CONCLUSIONS: Catheter-directed thrombolysis is a reliable and safe treatment modality for postnatal or abortion patients with DVT. CDT can reduce the incidence rate of PTS and increase the quality of life. International Scientific Literature, Inc. 2019-05-21 /pmc/articles/PMC6540639/ /pubmed/31110168 http://dx.doi.org/10.12659/MSM.914592 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Du, Xiaolong
Zhuang, Hao
Hong, Lei
Zhang, Yeqing
Li, Chenglong
Qian, Aimin
Sang, Hongfei
Li, Xiaoqiang
Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis
title Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis
title_full Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis
title_fullStr Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis
title_full_unstemmed Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis
title_short Long-Term Outcome of Catheter-Directed Thrombolysis in Pregnancy-Related Venous Thrombosis
title_sort long-term outcome of catheter-directed thrombolysis in pregnancy-related venous thrombosis
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540639/
https://www.ncbi.nlm.nih.gov/pubmed/31110168
http://dx.doi.org/10.12659/MSM.914592
work_keys_str_mv AT duxiaolong longtermoutcomeofcatheterdirectedthrombolysisinpregnancyrelatedvenousthrombosis
AT zhuanghao longtermoutcomeofcatheterdirectedthrombolysisinpregnancyrelatedvenousthrombosis
AT honglei longtermoutcomeofcatheterdirectedthrombolysisinpregnancyrelatedvenousthrombosis
AT zhangyeqing longtermoutcomeofcatheterdirectedthrombolysisinpregnancyrelatedvenousthrombosis
AT lichenglong longtermoutcomeofcatheterdirectedthrombolysisinpregnancyrelatedvenousthrombosis
AT qianaimin longtermoutcomeofcatheterdirectedthrombolysisinpregnancyrelatedvenousthrombosis
AT sanghongfei longtermoutcomeofcatheterdirectedthrombolysisinpregnancyrelatedvenousthrombosis
AT lixiaoqiang longtermoutcomeofcatheterdirectedthrombolysisinpregnancyrelatedvenousthrombosis