West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018

In 2018, there was a large West Nile virus (WNV) outbreak in northern Italy. We observed five atypical cases of WNV infection that were characterised by the presence of WNV RNA and WNV IgG at the time of diagnosis, but no IgM response during follow-up. Neutralisation assays demonstrated pre-existing...

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Autores principales: Sinigaglia, Alessandro, Pacenti, Monia, Martello, Thomas, Pagni, Silvana, Franchin, Elisa, Barzon, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540647/
https://www.ncbi.nlm.nih.gov/pubmed/31138361
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.21.1900261
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author Sinigaglia, Alessandro
Pacenti, Monia
Martello, Thomas
Pagni, Silvana
Franchin, Elisa
Barzon, Luisa
author_facet Sinigaglia, Alessandro
Pacenti, Monia
Martello, Thomas
Pagni, Silvana
Franchin, Elisa
Barzon, Luisa
author_sort Sinigaglia, Alessandro
collection PubMed
description In 2018, there was a large West Nile virus (WNV) outbreak in northern Italy. We observed five atypical cases of WNV infection that were characterised by the presence of WNV RNA and WNV IgG at the time of diagnosis, but no IgM response during follow-up. Neutralisation assays demonstrated pre-existing Usutu virus immunity in all patients. Besides challenging diagnosis, the immunological crosstalk between the two viruses warrants further investigation on possible cross-protection or infection enhancement effects.
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spelling pubmed-65406472019-06-12 West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018 Sinigaglia, Alessandro Pacenti, Monia Martello, Thomas Pagni, Silvana Franchin, Elisa Barzon, Luisa Euro Surveill Rapid Communication In 2018, there was a large West Nile virus (WNV) outbreak in northern Italy. We observed five atypical cases of WNV infection that were characterised by the presence of WNV RNA and WNV IgG at the time of diagnosis, but no IgM response during follow-up. Neutralisation assays demonstrated pre-existing Usutu virus immunity in all patients. Besides challenging diagnosis, the immunological crosstalk between the two viruses warrants further investigation on possible cross-protection or infection enhancement effects. European Centre for Disease Prevention and Control (ECDC) 2019-05-23 /pmc/articles/PMC6540647/ /pubmed/31138361 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.21.1900261 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Sinigaglia, Alessandro
Pacenti, Monia
Martello, Thomas
Pagni, Silvana
Franchin, Elisa
Barzon, Luisa
West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018
title West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018
title_full West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018
title_fullStr West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018
title_full_unstemmed West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018
title_short West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018
title_sort west nile virus infection in individuals with pre-existing usutu virus immunity, northern italy, 2018
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540647/
https://www.ncbi.nlm.nih.gov/pubmed/31138361
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.21.1900261
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