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Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes
Inflammation is an important contributor to the pathogenesis of obesity-related type 2 diabetes (T2D). Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540829/ https://www.ncbi.nlm.nih.gov/pubmed/31191541 http://dx.doi.org/10.3389/fimmu.2019.01173 |
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author | Lu, Jingli Zhao, Junjie Meng, Haiyang Zhang, Xiaojian |
author_facet | Lu, Jingli Zhao, Junjie Meng, Haiyang Zhang, Xiaojian |
author_sort | Lu, Jingli |
collection | PubMed |
description | Inflammation is an important contributor to the pathogenesis of obesity-related type 2 diabetes (T2D). Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose tissue-resident immune cells that are dysregulated in the context of obesity and T2D. We comprehensively overviewed emerging knowledge regarding the phenotypic and functional properties of these cells and local factors that control their development. We discussed their function in controlling the immune response cascade and disease progression. We also characterized the metabolic profiles of these cells to explain the functional consequences in obese adipose tissues. Finally, we discussed the potential therapeutic targeting of adipose tissue-resident immune cells with the aim of addressing novel therapeutic approaches for the treatment of this disease. |
format | Online Article Text |
id | pubmed-6540829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65408292019-06-12 Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes Lu, Jingli Zhao, Junjie Meng, Haiyang Zhang, Xiaojian Front Immunol Immunology Inflammation is an important contributor to the pathogenesis of obesity-related type 2 diabetes (T2D). Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose tissue-resident immune cells that are dysregulated in the context of obesity and T2D. We comprehensively overviewed emerging knowledge regarding the phenotypic and functional properties of these cells and local factors that control their development. We discussed their function in controlling the immune response cascade and disease progression. We also characterized the metabolic profiles of these cells to explain the functional consequences in obese adipose tissues. Finally, we discussed the potential therapeutic targeting of adipose tissue-resident immune cells with the aim of addressing novel therapeutic approaches for the treatment of this disease. Frontiers Media S.A. 2019-05-22 /pmc/articles/PMC6540829/ /pubmed/31191541 http://dx.doi.org/10.3389/fimmu.2019.01173 Text en Copyright © 2019 Lu, Zhao, Meng and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lu, Jingli Zhao, Junjie Meng, Haiyang Zhang, Xiaojian Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes |
title | Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes |
title_full | Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes |
title_fullStr | Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes |
title_full_unstemmed | Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes |
title_short | Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes |
title_sort | adipose tissue-resident immune cells in obesity and type 2 diabetes |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540829/ https://www.ncbi.nlm.nih.gov/pubmed/31191541 http://dx.doi.org/10.3389/fimmu.2019.01173 |
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