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Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes

Inflammation is an important contributor to the pathogenesis of obesity-related type 2 diabetes (T2D). Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose...

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Autores principales: Lu, Jingli, Zhao, Junjie, Meng, Haiyang, Zhang, Xiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540829/
https://www.ncbi.nlm.nih.gov/pubmed/31191541
http://dx.doi.org/10.3389/fimmu.2019.01173
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author Lu, Jingli
Zhao, Junjie
Meng, Haiyang
Zhang, Xiaojian
author_facet Lu, Jingli
Zhao, Junjie
Meng, Haiyang
Zhang, Xiaojian
author_sort Lu, Jingli
collection PubMed
description Inflammation is an important contributor to the pathogenesis of obesity-related type 2 diabetes (T2D). Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose tissue-resident immune cells that are dysregulated in the context of obesity and T2D. We comprehensively overviewed emerging knowledge regarding the phenotypic and functional properties of these cells and local factors that control their development. We discussed their function in controlling the immune response cascade and disease progression. We also characterized the metabolic profiles of these cells to explain the functional consequences in obese adipose tissues. Finally, we discussed the potential therapeutic targeting of adipose tissue-resident immune cells with the aim of addressing novel therapeutic approaches for the treatment of this disease.
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spelling pubmed-65408292019-06-12 Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes Lu, Jingli Zhao, Junjie Meng, Haiyang Zhang, Xiaojian Front Immunol Immunology Inflammation is an important contributor to the pathogenesis of obesity-related type 2 diabetes (T2D). Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose tissue-resident immune cells that are dysregulated in the context of obesity and T2D. We comprehensively overviewed emerging knowledge regarding the phenotypic and functional properties of these cells and local factors that control their development. We discussed their function in controlling the immune response cascade and disease progression. We also characterized the metabolic profiles of these cells to explain the functional consequences in obese adipose tissues. Finally, we discussed the potential therapeutic targeting of adipose tissue-resident immune cells with the aim of addressing novel therapeutic approaches for the treatment of this disease. Frontiers Media S.A. 2019-05-22 /pmc/articles/PMC6540829/ /pubmed/31191541 http://dx.doi.org/10.3389/fimmu.2019.01173 Text en Copyright © 2019 Lu, Zhao, Meng and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lu, Jingli
Zhao, Junjie
Meng, Haiyang
Zhang, Xiaojian
Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes
title Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes
title_full Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes
title_fullStr Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes
title_full_unstemmed Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes
title_short Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes
title_sort adipose tissue-resident immune cells in obesity and type 2 diabetes
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540829/
https://www.ncbi.nlm.nih.gov/pubmed/31191541
http://dx.doi.org/10.3389/fimmu.2019.01173
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