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Molecular Understanding of Hearing – How Does This Matter to the Hearing Impaired?
This review addresses the advances of our molecular understanding of hearing and how this benefits the hearing impaired. Classical biochemical methods usually fall short in contributing to the analysis of the molecular mechanisms of hearing e. g. in the cochlea, the auditory part of the inner ear, d...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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© Georg Thieme Verlag KG
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541096/ https://www.ncbi.nlm.nih.gov/pubmed/29905358 http://dx.doi.org/10.1055/s-0043-121595 |
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author | Moser, Tobias |
author_facet | Moser, Tobias |
author_sort | Moser, Tobias |
collection | PubMed |
description | This review addresses the advances of our molecular understanding of hearing and how this benefits the hearing impaired. Classical biochemical methods usually fall short in contributing to the analysis of the molecular mechanisms of hearing e. g. in the cochlea, the auditory part of the inner ear, due to the scarcity of the cells of interest. Genetics, molecular cell biology, and physiology, on the other hand, have elucidated the intricate molecular and cellular mechanisms that bring about the outstanding performance of the auditory system. Many of those mechanisms are quite unique and specialized to serve the specific needs of hearing. Hence, their defects often spare other organs and lead to specific non-syndromic deafness. High throughput sequencing can reveal causes of sporadic deafness when combined with careful bioinformatics. Molecular approaches are also helpful for understanding more common forms of hearing impairment such as noise-induced hearing impairment. While molecular therapies are not yet clinically available, careful molecular genetic analysis helps to counsel the hearing impaired subjects. |
format | Online Article Text |
id | pubmed-6541096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | © Georg Thieme Verlag KG |
record_format | MEDLINE/PubMed |
spelling | pubmed-65410962019-05-30 Molecular Understanding of Hearing – How Does This Matter to the Hearing Impaired? Moser, Tobias Laryngorhinootologie This review addresses the advances of our molecular understanding of hearing and how this benefits the hearing impaired. Classical biochemical methods usually fall short in contributing to the analysis of the molecular mechanisms of hearing e. g. in the cochlea, the auditory part of the inner ear, due to the scarcity of the cells of interest. Genetics, molecular cell biology, and physiology, on the other hand, have elucidated the intricate molecular and cellular mechanisms that bring about the outstanding performance of the auditory system. Many of those mechanisms are quite unique and specialized to serve the specific needs of hearing. Hence, their defects often spare other organs and lead to specific non-syndromic deafness. High throughput sequencing can reveal causes of sporadic deafness when combined with careful bioinformatics. Molecular approaches are also helpful for understanding more common forms of hearing impairment such as noise-induced hearing impairment. While molecular therapies are not yet clinically available, careful molecular genetic analysis helps to counsel the hearing impaired subjects. © Georg Thieme Verlag KG 2018-03 2018-03-22 /pmc/articles/PMC6541096/ /pubmed/29905358 http://dx.doi.org/10.1055/s-0043-121595 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Moser, Tobias Molecular Understanding of Hearing – How Does This Matter to the Hearing Impaired? |
title | Molecular Understanding of Hearing – How Does This Matter to the Hearing Impaired? |
title_full | Molecular Understanding of Hearing – How Does This Matter to the Hearing Impaired? |
title_fullStr | Molecular Understanding of Hearing – How Does This Matter to the Hearing Impaired? |
title_full_unstemmed | Molecular Understanding of Hearing – How Does This Matter to the Hearing Impaired? |
title_short | Molecular Understanding of Hearing – How Does This Matter to the Hearing Impaired? |
title_sort | molecular understanding of hearing – how does this matter to the hearing impaired? |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541096/ https://www.ncbi.nlm.nih.gov/pubmed/29905358 http://dx.doi.org/10.1055/s-0043-121595 |
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