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Role of Adiponectin in prostate cancer

Obesity is defined as a chronic and excessive growth of adipose tissue. It has been associated with a high risk for development and progression of obesity-associated malignancies, while adipokines may mediate this association. Adiponectin is an adipose tissue-derived adipokines, with significant ant...

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Autores principales: Hu, Xiaobo, Hu, Cong, Zhang, Caiping, Zhang, Min, Long, Shiyin, Cao, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Urologia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541146/
https://www.ncbi.nlm.nih.gov/pubmed/30648824
http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0261
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author Hu, Xiaobo
Hu, Cong
Zhang, Caiping
Zhang, Min
Long, Shiyin
Cao, Zhaohui
author_facet Hu, Xiaobo
Hu, Cong
Zhang, Caiping
Zhang, Min
Long, Shiyin
Cao, Zhaohui
author_sort Hu, Xiaobo
collection PubMed
description Obesity is defined as a chronic and excessive growth of adipose tissue. It has been associated with a high risk for development and progression of obesity-associated malignancies, while adipokines may mediate this association. Adiponectin is an adipose tissue-derived adipokines, with significant anti-diabetic, anti-inflammatory, anti-atherosclerotic and anti-proliferative properties. Plasma adiponectin levels are decreased in obese individuals, and this feature is closely correlated with development of several metabolic, immunological and neoplastic diseases. Recent studies have shown that prostate cancer patients have lower serum adiponectin levels and decreased expression of adiponectin receptors in tumor tissues, which suggests plasma adiponectin level is a risk factor for prostate cancer. Furthermore, exogenous adiponectin has exhibited therapeutic potential in animal models. In this review, we focus on the potential role of adiponectin and the underlying mechanism of adiponectin in the development and progression of prostate cancer. Exploring the signaling pathways linking adiponectin with tumorigenesis might provide a potential target for therapy.
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spelling pubmed-65411462019-06-12 Role of Adiponectin in prostate cancer Hu, Xiaobo Hu, Cong Zhang, Caiping Zhang, Min Long, Shiyin Cao, Zhaohui Int Braz J Urol Review Article Obesity is defined as a chronic and excessive growth of adipose tissue. It has been associated with a high risk for development and progression of obesity-associated malignancies, while adipokines may mediate this association. Adiponectin is an adipose tissue-derived adipokines, with significant anti-diabetic, anti-inflammatory, anti-atherosclerotic and anti-proliferative properties. Plasma adiponectin levels are decreased in obese individuals, and this feature is closely correlated with development of several metabolic, immunological and neoplastic diseases. Recent studies have shown that prostate cancer patients have lower serum adiponectin levels and decreased expression of adiponectin receptors in tumor tissues, which suggests plasma adiponectin level is a risk factor for prostate cancer. Furthermore, exogenous adiponectin has exhibited therapeutic potential in animal models. In this review, we focus on the potential role of adiponectin and the underlying mechanism of adiponectin in the development and progression of prostate cancer. Exploring the signaling pathways linking adiponectin with tumorigenesis might provide a potential target for therapy. Sociedade Brasileira de Urologia 2019-04-01 /pmc/articles/PMC6541146/ /pubmed/30648824 http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0261 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hu, Xiaobo
Hu, Cong
Zhang, Caiping
Zhang, Min
Long, Shiyin
Cao, Zhaohui
Role of Adiponectin in prostate cancer
title Role of Adiponectin in prostate cancer
title_full Role of Adiponectin in prostate cancer
title_fullStr Role of Adiponectin in prostate cancer
title_full_unstemmed Role of Adiponectin in prostate cancer
title_short Role of Adiponectin in prostate cancer
title_sort role of adiponectin in prostate cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541146/
https://www.ncbi.nlm.nih.gov/pubmed/30648824
http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0261
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