Lessening of porcine epidemic diarrhoea virus susceptibility in piglets after editing of the CMP-N-glycolylneuraminic acid hydroxylase gene with CRISPR/Cas9 to nullify N-glycolylneuraminic acid expression

The porcine epidemic diarrhoea virus (PEDV) devastates the health of piglets but may not infect piglets whose CMP-N-glycolylneuraminic acid hydroxylase (CMAH) gene is mutated (knockouts, KO) by using CRISPR/Cas9 gene editing techniques. This hypothesis was tested by using KO piglets that were challe...

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Detalles Bibliográficos
Autores principales: Tu, Ching-Fu, Chuang, Chin-kai, Hsiao, Kai-Hsuan, Chen, Chien-Hong, Chen, Chi-Min, Peng, Su-Hei, Su, Yu-Hsiu, Chiou, Ming-Tang, Yen, Chon-Ho, Hung, Shao-Wen, Yang, Tien-Shuh, Chen, Chuan-Mu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541307/
https://www.ncbi.nlm.nih.gov/pubmed/31141512
http://dx.doi.org/10.1371/journal.pone.0217236

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