SO(2)F(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes

A catalyst-free novel and efficient methodology for the challenging synthesis of benzo-oxetes from 2'-hydroxyacetophenones mediated by sulfuryl fluoride (SO(2)F(2)) gas has been realized. The combination of 2'-hydroxyacetophenones and SO(2)F(2) furnishes synthetically challenging benzo-oxe...

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Autores principales: Lekkala, Revathi, Lekkala, Ravindar, Moku, Balakrishna, Rakesh, K P, Qin, Hua-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541378/
https://www.ncbi.nlm.nih.gov/pubmed/31164935
http://dx.doi.org/10.3762/bjoc.15.95
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author Lekkala, Revathi
Lekkala, Ravindar
Moku, Balakrishna
Rakesh, K P
Qin, Hua-Li
author_facet Lekkala, Revathi
Lekkala, Ravindar
Moku, Balakrishna
Rakesh, K P
Qin, Hua-Li
author_sort Lekkala, Revathi
collection PubMed
description A catalyst-free novel and efficient methodology for the challenging synthesis of benzo-oxetes from 2'-hydroxyacetophenones mediated by sulfuryl fluoride (SO(2)F(2)) gas has been realized. The combination of 2'-hydroxyacetophenones and SO(2)F(2) furnishes synthetically challenging benzo-oxetanes in moderate to excellent yields. The highlight of this work is the design and synthesis of strained four-membered oxete rings.
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spelling pubmed-65413782019-06-04 SO(2)F(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes Lekkala, Revathi Lekkala, Ravindar Moku, Balakrishna Rakesh, K P Qin, Hua-Li Beilstein J Org Chem Letter A catalyst-free novel and efficient methodology for the challenging synthesis of benzo-oxetes from 2'-hydroxyacetophenones mediated by sulfuryl fluoride (SO(2)F(2)) gas has been realized. The combination of 2'-hydroxyacetophenones and SO(2)F(2) furnishes synthetically challenging benzo-oxetanes in moderate to excellent yields. The highlight of this work is the design and synthesis of strained four-membered oxete rings. Beilstein-Institut 2019-04-25 /pmc/articles/PMC6541378/ /pubmed/31164935 http://dx.doi.org/10.3762/bjoc.15.95 Text en Copyright © 2019, Lekkala et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Lekkala, Revathi
Lekkala, Ravindar
Moku, Balakrishna
Rakesh, K P
Qin, Hua-Li
SO(2)F(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes
title SO(2)F(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes
title_full SO(2)F(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes
title_fullStr SO(2)F(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes
title_full_unstemmed SO(2)F(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes
title_short SO(2)F(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes
title_sort so(2)f(2)-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541378/
https://www.ncbi.nlm.nih.gov/pubmed/31164935
http://dx.doi.org/10.3762/bjoc.15.95
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