Early divergence of mutational processes in human fetal tissues

A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were ab...

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Detalles Bibliográficos
Autores principales: Kuijk, Ewart, Blokzijl, Francis, Jager, Myrthe, Besselink, Nicolle, Boymans, Sander, Chuva de Sousa Lopes, Susana M., van Boxtel, Ruben, Cuppen, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541467/
https://www.ncbi.nlm.nih.gov/pubmed/31149636
http://dx.doi.org/10.1126/sciadv.aaw1271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541467/
https://www.ncbi.nlm.nih.gov/pubmed/31149636
http://dx.doi.org/10.1126/sciadv.aaw1271

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