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Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV
Despite treatment, immune activation is thought to contribute to cerebral injury in children perinatally infected with human immunodeficiency virus (HIV). We aimed to characterize immune activation in relation to neuroimaging and cognitive outcomes. We therefore measured immunological, coagulation,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541601/ https://www.ncbi.nlm.nih.gov/pubmed/31142789 http://dx.doi.org/10.1038/s41598-019-44198-z |
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author | Blokhuis, C. Peeters, C. F. W. Cohen, S. Scherpbier, H. J. Kuijpers, T. W. Reiss, P. Kootstra, N. A. Teunissen, C. E. Pajkrt, D. |
author_facet | Blokhuis, C. Peeters, C. F. W. Cohen, S. Scherpbier, H. J. Kuijpers, T. W. Reiss, P. Kootstra, N. A. Teunissen, C. E. Pajkrt, D. |
author_sort | Blokhuis, C. |
collection | PubMed |
description | Despite treatment, immune activation is thought to contribute to cerebral injury in children perinatally infected with human immunodeficiency virus (HIV). We aimed to characterize immune activation in relation to neuroimaging and cognitive outcomes. We therefore measured immunological, coagulation, and neuronal biomarkers in plasma and cerebrospinal fluid (CSF) samples of 34 perinatally HIV-infected children aged 8–18 years, and in plasma samples of 37 controls of comparable age, sex, ethnicity, and socio-economic status. We then compared plasma biomarker levels between groups, and explored associations between plasma/CSF biomarkers and neuroimaging and cognitive outcomes using network analysis. HIV-infected children showed higher plasma levels of C-reactive protein, interferon-gamma, interferon-gamma-inducible protein-10, and monocyte chemoattractant protein-1 than controls. In HIV-infected participants, plasma soluble CD14 was positively associated with microstructural white matter (WM) damage, and plasma D-dimer was negatively associated with WM blood flow. In CSF, IL-6 was negatively associated with WM volume, and neurofilament heavy-chain (NFH) was negatively associated with intelligence quotient and working memory. These markers of ongoing inflammation, immune activation, coagulation, and neuronal damage could be used to further evaluate the pathophysiology and clinical course of cerebral and cognitive deficits in perinatally acquired HIV. |
format | Online Article Text |
id | pubmed-6541601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65416012019-06-07 Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV Blokhuis, C. Peeters, C. F. W. Cohen, S. Scherpbier, H. J. Kuijpers, T. W. Reiss, P. Kootstra, N. A. Teunissen, C. E. Pajkrt, D. Sci Rep Article Despite treatment, immune activation is thought to contribute to cerebral injury in children perinatally infected with human immunodeficiency virus (HIV). We aimed to characterize immune activation in relation to neuroimaging and cognitive outcomes. We therefore measured immunological, coagulation, and neuronal biomarkers in plasma and cerebrospinal fluid (CSF) samples of 34 perinatally HIV-infected children aged 8–18 years, and in plasma samples of 37 controls of comparable age, sex, ethnicity, and socio-economic status. We then compared plasma biomarker levels between groups, and explored associations between plasma/CSF biomarkers and neuroimaging and cognitive outcomes using network analysis. HIV-infected children showed higher plasma levels of C-reactive protein, interferon-gamma, interferon-gamma-inducible protein-10, and monocyte chemoattractant protein-1 than controls. In HIV-infected participants, plasma soluble CD14 was positively associated with microstructural white matter (WM) damage, and plasma D-dimer was negatively associated with WM blood flow. In CSF, IL-6 was negatively associated with WM volume, and neurofilament heavy-chain (NFH) was negatively associated with intelligence quotient and working memory. These markers of ongoing inflammation, immune activation, coagulation, and neuronal damage could be used to further evaluate the pathophysiology and clinical course of cerebral and cognitive deficits in perinatally acquired HIV. Nature Publishing Group UK 2019-05-29 /pmc/articles/PMC6541601/ /pubmed/31142789 http://dx.doi.org/10.1038/s41598-019-44198-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Blokhuis, C. Peeters, C. F. W. Cohen, S. Scherpbier, H. J. Kuijpers, T. W. Reiss, P. Kootstra, N. A. Teunissen, C. E. Pajkrt, D. Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV |
title | Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV |
title_full | Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV |
title_fullStr | Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV |
title_full_unstemmed | Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV |
title_short | Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV |
title_sort | systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric hiv |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541601/ https://www.ncbi.nlm.nih.gov/pubmed/31142789 http://dx.doi.org/10.1038/s41598-019-44198-z |
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