Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Stabilized HIV-1 envelope glycoproteins (Env) that resemble the native Env are utilized in vaccination strategies aimed at inducing broadly neutralizing antibodies (bNAbs). To limit the exposure of rare isolate-specific antigenic residues/determinants we generated a SOSIP trimer based on a consensus...

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Detalles Bibliográficos
Autores principales: Sliepen, Kwinten, Han, Byung Woo, Bontjer, Ilja, Mooij, Petra, Garces, Fernando, Behrens, Anna-Janina, Rantalainen, Kimmo, Kumar, Sonu, Sarkar, Anita, Brouwer, Philip J. M., Hua, Yuanzi, Tolazzi, Monica, Schermer, Edith, Torres, Jonathan L., Ozorowski, Gabriel, van der Woude, Patricia, de la Peña, Alba Torrents, van Breemen, Mariëlle J., Camacho-Sánchez, Juan Miguel, Burger, Judith A., Medina-Ramírez, Max, González, Nuria, Alcami, Jose, LaBranche, Celia, Scarlatti, Gabriella, van Gils, Marit J., Crispin, Max, Montefiori, David C., Ward, Andrew B., Koopman, Gerrit, Moore, John P., Shattock, Robin J., Bogers, Willy M., Wilson, Ian A., Sanders, Rogier W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541627/
https://www.ncbi.nlm.nih.gov/pubmed/31142746
http://dx.doi.org/10.1038/s41467-019-10262-5

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