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Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone

Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstruc...

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Autores principales: Yoshioka, Yohsuke, Yamachika, Eiki, Nakanishi, Makoto, Ninomiya, Tadashi, Akashi, Sho, Kondo, Sei, Moritani, Norifumi, Kobayashi, Yasuhiro, Fujii, Tatsuo, Iida, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541641/
https://www.ncbi.nlm.nih.gov/pubmed/31142769
http://dx.doi.org/10.1038/s41598-019-44389-8
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author Yoshioka, Yohsuke
Yamachika, Eiki
Nakanishi, Makoto
Ninomiya, Tadashi
Akashi, Sho
Kondo, Sei
Moritani, Norifumi
Kobayashi, Yasuhiro
Fujii, Tatsuo
Iida, Seiji
author_facet Yoshioka, Yohsuke
Yamachika, Eiki
Nakanishi, Makoto
Ninomiya, Tadashi
Akashi, Sho
Kondo, Sei
Moritani, Norifumi
Kobayashi, Yasuhiro
Fujii, Tatsuo
Iida, Seiji
author_sort Yoshioka, Yohsuke
collection PubMed
description Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.
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spelling pubmed-65416412019-06-07 Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone Yoshioka, Yohsuke Yamachika, Eiki Nakanishi, Makoto Ninomiya, Tadashi Akashi, Sho Kondo, Sei Moritani, Norifumi Kobayashi, Yasuhiro Fujii, Tatsuo Iida, Seiji Sci Rep Article Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation. Nature Publishing Group UK 2019-05-29 /pmc/articles/PMC6541641/ /pubmed/31142769 http://dx.doi.org/10.1038/s41598-019-44389-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yoshioka, Yohsuke
Yamachika, Eiki
Nakanishi, Makoto
Ninomiya, Tadashi
Akashi, Sho
Kondo, Sei
Moritani, Norifumi
Kobayashi, Yasuhiro
Fujii, Tatsuo
Iida, Seiji
Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone
title Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone
title_full Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone
title_fullStr Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone
title_full_unstemmed Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone
title_short Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone
title_sort intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541641/
https://www.ncbi.nlm.nih.gov/pubmed/31142769
http://dx.doi.org/10.1038/s41598-019-44389-8
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