Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial

In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Di...

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Detalles Bibliográficos
Autores principales: Porco, Travis C, Hart, John, Arzika, Ahmed M, Weaver, Jerusha, Kalua, Khumbo, Mrango, Zakayo, Cotter, Sun Y, Stoller, Nicole E, O’Brien, Kieran S, Fry, Dionna M, Vanderschelden, Benjamin, Oldenburg, Catherine E, West, Sheila K, Bailey, Robin L, Keenan, Jeremy D, Lietman, Thomas M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541729/
https://www.ncbi.nlm.nih.gov/pubmed/30561577
http://dx.doi.org/10.1093/cid/ciy973
Descripción
Sumario:In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.

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