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Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial
In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Di...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541729/ https://www.ncbi.nlm.nih.gov/pubmed/30561577 http://dx.doi.org/10.1093/cid/ciy973 |
| _version_ | 1783422815168364544 |
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| author | Porco, Travis C Hart, John Arzika, Ahmed M Weaver, Jerusha Kalua, Khumbo Mrango, Zakayo Cotter, Sun Y Stoller, Nicole E O’Brien, Kieran S Fry, Dionna M Vanderschelden, Benjamin Oldenburg, Catherine E West, Sheila K Bailey, Robin L Keenan, Jeremy D Lietman, Thomas M |
| author_facet | Porco, Travis C Hart, John Arzika, Ahmed M Weaver, Jerusha Kalua, Khumbo Mrango, Zakayo Cotter, Sun Y Stoller, Nicole E O’Brien, Kieran S Fry, Dionna M Vanderschelden, Benjamin Oldenburg, Catherine E West, Sheila K Bailey, Robin L Keenan, Jeremy D Lietman, Thomas M |
| author_sort | Porco, Travis C |
| collection | PubMed |
| description | In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981. |
| format | Online Article Text |
| id | pubmed-6541729 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-65417292019-06-11 Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial Porco, Travis C Hart, John Arzika, Ahmed M Weaver, Jerusha Kalua, Khumbo Mrango, Zakayo Cotter, Sun Y Stoller, Nicole E O’Brien, Kieran S Fry, Dionna M Vanderschelden, Benjamin Oldenburg, Catherine E West, Sheila K Bailey, Robin L Keenan, Jeremy D Lietman, Thomas M Clin Infect Dis Brief Reports In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981. Oxford University Press 2019-06-15 2018-12-17 /pmc/articles/PMC6541729/ /pubmed/30561577 http://dx.doi.org/10.1093/cid/ciy973 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Reports Porco, Travis C Hart, John Arzika, Ahmed M Weaver, Jerusha Kalua, Khumbo Mrango, Zakayo Cotter, Sun Y Stoller, Nicole E O’Brien, Kieran S Fry, Dionna M Vanderschelden, Benjamin Oldenburg, Catherine E West, Sheila K Bailey, Robin L Keenan, Jeremy D Lietman, Thomas M Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial |
| title | Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial |
| title_full | Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial |
| title_fullStr | Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial |
| title_full_unstemmed | Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial |
| title_short | Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial |
| title_sort | mass oral azithromycin for childhood mortality: timing of death after distribution in the mordor trial |
| topic | Brief Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541729/ https://www.ncbi.nlm.nih.gov/pubmed/30561577 http://dx.doi.org/10.1093/cid/ciy973 |
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