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Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H(2)O Metabolism Pilot Study
OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose. DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (>10.7 pmol · L(−1) i...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Endocrine Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541888/ https://www.ncbi.nlm.nih.gov/pubmed/30566641 http://dx.doi.org/10.1210/jc.2018-02195 |
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author | Enhörning, Sofia Brunkwall, Louise Tasevska, Irina Ericson, Ulrika Persson Tholin, Jenny Persson, Margaretha Lemetais, Guillaume Vanhaecke, Tiphaine Dolci, Alberto Perrier, Erica T Melander, Olle |
author_facet | Enhörning, Sofia Brunkwall, Louise Tasevska, Irina Ericson, Ulrika Persson Tholin, Jenny Persson, Margaretha Lemetais, Guillaume Vanhaecke, Tiphaine Dolci, Alberto Perrier, Erica T Melander, Olle |
author_sort | Enhörning, Sofia |
collection | PubMed |
description | OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose. DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (>10.7 pmol · L(−1) in men and >6.1 pmol·L(−1) in women) identified in a population-based survey from 2013 to 2015 and with a current 24-hour urine osmolality of >600 mOsm · kg(−1) were included. INTERVENTION: Addition of 1.5 L water daily on top of habitual fluid intake for 6 weeks. MAIN OUTCOME MEASURE: Pre- and postintervention fasting plasma copeptin concentrations. RESULTS: Reported mean water intake increased from 0.43 to 1.35 L · d(−1) (P < 0.001), with no other observed changes in diet. Median (interquartile range) urine osmolality was reduced from 879 (705, 996) to 384 (319, 502) mOsm · kg(−1) (P < 0.001); urine volume increased from 1.06 (0.90, 1.20) to 2.27 (1.52, 2.67) L · d(−1) (P < 0.001); and baseline copeptin decreased from 12.9 (7.4, 21.9) pmol · L(−1) to 7.8 (4.6;11.3) pmol · L(−1) (P < 0.001). Water supplementation reduced fasting plasma glucose from a mean (SD) of 5.94 (0.44) to 5.74 (0.51) (P = 0.04). The water-associated reduction of both fasting copeptin and glucose concentration in plasma was most pronounced in participants in the top tertile of baseline copeptin. CONCLUSIONS: Water supplementation in persons with habitually low water consumption and high copeptin levels is effective in lowering copeptin. It appears a safe and promising intervention with the potential of lowering fasting plasma glucose and thus reducing diabetes risk. Further investigations are warranted to support these findings. |
format | Online Article Text |
id | pubmed-6541888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-65418882019-06-11 Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H(2)O Metabolism Pilot Study Enhörning, Sofia Brunkwall, Louise Tasevska, Irina Ericson, Ulrika Persson Tholin, Jenny Persson, Margaretha Lemetais, Guillaume Vanhaecke, Tiphaine Dolci, Alberto Perrier, Erica T Melander, Olle J Clin Endocrinol Metab Clinical Research Articles OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose. DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (>10.7 pmol · L(−1) in men and >6.1 pmol·L(−1) in women) identified in a population-based survey from 2013 to 2015 and with a current 24-hour urine osmolality of >600 mOsm · kg(−1) were included. INTERVENTION: Addition of 1.5 L water daily on top of habitual fluid intake for 6 weeks. MAIN OUTCOME MEASURE: Pre- and postintervention fasting plasma copeptin concentrations. RESULTS: Reported mean water intake increased from 0.43 to 1.35 L · d(−1) (P < 0.001), with no other observed changes in diet. Median (interquartile range) urine osmolality was reduced from 879 (705, 996) to 384 (319, 502) mOsm · kg(−1) (P < 0.001); urine volume increased from 1.06 (0.90, 1.20) to 2.27 (1.52, 2.67) L · d(−1) (P < 0.001); and baseline copeptin decreased from 12.9 (7.4, 21.9) pmol · L(−1) to 7.8 (4.6;11.3) pmol · L(−1) (P < 0.001). Water supplementation reduced fasting plasma glucose from a mean (SD) of 5.94 (0.44) to 5.74 (0.51) (P = 0.04). The water-associated reduction of both fasting copeptin and glucose concentration in plasma was most pronounced in participants in the top tertile of baseline copeptin. CONCLUSIONS: Water supplementation in persons with habitually low water consumption and high copeptin levels is effective in lowering copeptin. It appears a safe and promising intervention with the potential of lowering fasting plasma glucose and thus reducing diabetes risk. Further investigations are warranted to support these findings. Endocrine Society 2018-12-18 /pmc/articles/PMC6541888/ /pubmed/30566641 http://dx.doi.org/10.1210/jc.2018-02195 Text en Copyright © 2019 Endocrine Society https://creativecommons.org/licenses/by/4.0/ This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Clinical Research Articles Enhörning, Sofia Brunkwall, Louise Tasevska, Irina Ericson, Ulrika Persson Tholin, Jenny Persson, Margaretha Lemetais, Guillaume Vanhaecke, Tiphaine Dolci, Alberto Perrier, Erica T Melander, Olle Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H(2)O Metabolism Pilot Study |
title | Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H(2)O Metabolism Pilot Study |
title_full | Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H(2)O Metabolism Pilot Study |
title_fullStr | Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H(2)O Metabolism Pilot Study |
title_full_unstemmed | Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H(2)O Metabolism Pilot Study |
title_short | Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H(2)O Metabolism Pilot Study |
title_sort | water supplementation reduces copeptin and plasma glucose in adults with high copeptin: the h(2)o metabolism pilot study |
topic | Clinical Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541888/ https://www.ncbi.nlm.nih.gov/pubmed/30566641 http://dx.doi.org/10.1210/jc.2018-02195 |
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