Cargando…

DCLK1 Plays a Metastatic-Promoting Role in Human Breast Cancer Cells

BACKGROUND: Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. However, there is little data regarding the functional role of DCLK1 in breast cancer metastasis. In th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Heshu, Wen, Tao, Zhou, Ying, Fan, Xiaona, Du, Tan, Gao, Tianbo, Li, Lina, Liu, Jian, Yang, Lei, Yao, Jiannan, Ge, Yang, An, Guangyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541964/ https://www.ncbi.nlm.nih.gov/pubmed/31223610 http://dx.doi.org/10.1155/2019/1061979

Ejemplares similares

DCLK1 Suppresses Tumor-Specific Cytotoxic T Lymphocyte Function Through Recruitment of MDSCs via the CXCL1-CXCR2 Axis
por: Yan, Rui, et al.
Publicado: (2022)

Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling
por: Liu, Heshu, et al.
Publicado: (2023)

Inhibition of DCLK1 kinase reverses epithelial-mesenchymal transition and restores T-cell activity in pancreatic ductal adenocarcinoma
por: Ge, Yang, et al.
Publicado: (2022)

DCLK1 Drives EGFR-TKI-Acquired Resistance in Lung Adenocarcinoma by Remodeling the Epithelial–Mesenchymal Transition Status
por: Yan, Rui, et al.
Publicado: (2023)

Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity
por: Ding, Ling, et al.
Publicado: (2021)

Combination of anlotinib and gemcitabine promotes the G0/G1 cell cycle arrest and apoptosis of intrahepatic cholangiocarcinoma in vitro
por: Fan, Shanshan, et al.
Publicado: (2021)

Development and Validation of a Prognostic Gene Signature Correlated With M2 Macrophage Infiltration in Esophageal Squamous Cell Carcinoma
por: Yao, Jiannan, et al.
Publicado: (2021)

Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells
por: Chandrakesan, Parthasarathy, et al.
Publicado: (2017)

DCLK1 autoinhibition and activation in tumorigenesis
por: Cheng, Linna, et al.
Publicado: (2021)

DCLK1 immunoreactivity in colorectal neoplasia
por: Gagliardi, Giuseppe, et al.
Publicado: (2012)

Analysis of the clinical significance of DCLK1(+) colorectal cancer using novel monoclonal antibodies against DCLK1
por: Dai, Tianqi, et al.
Publicado: (2018)

Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer
por: Qu, Dongfeng, et al.
Publicado: (2019)

Structural Basis of Inhibition of DCLK1 by Ruxolitinib
por: Jang, Dong Man, et al.
Publicado: (2021)

Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
por: Huang, Zhuqi, et al.
Publicado: (2023)

XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression
por: Yang, Wei-Qiang, et al.
Publicado: (2021)

Pleiotropic effects of DCLK1 in cancer and cancer stem cells
por: Chhetri, Dibyashree, et al.
Publicado: (2022)

Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway
por: Yang, Bin, et al.
Publicado: (2023)

DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis
por: Kim, Jee-Heun, et al.
Publicado: (2022)

Corrigendum to “Construction of a novel immune response prediction signature to predict the efficacy of immune checkpoint inhibitors in clear cell renal cell carcinoma patients” Heliyon 9(6), (May 25, 2023)()
por: Yao, Jiannan, et al.
Publicado: (2023)

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin
por: Galvan, Laurie, et al.
Publicado: (2018)

DCLK1, a Putative Stem Cell Marker in Human Cholangiocarcinoma
por: Lorenzo, Nevi, et al.
Publicado: (2021)

DCLK1 Inhibition Sensitizes Colorectal Cancer Cells to Radiation Treatment
por: Mohammadi, Chiman, et al.
Publicado: (2021)

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases
por: Venkat, Aarya, et al.
Publicado: (2023)

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis
por: Carli, Annalisa L. E., et al.
Publicado: (2023)

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases
por: Venkat, Aarya, et al.
Publicado: (2023)

Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism
por: Sureban, Sripathi M., et al.
Publicado: (2015)

MicroRNA-223-5p suppresses the progression of nasopharyngeal carcinoma by targeting DCLK1
por: Zhang, Zhixuan, et al.
Publicado: (2021)

Rapid assessment of DCLK1 inhibitors using a peptide substrate mobility shift assay
por: Liu, Yan, et al.
Publicado: (2021)

CLEC3B is downregulated and inhibits proliferation in clear cell renal cell carcinoma
por: Liu, Jian, et al.
Publicado: (2018)

Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications
por: O’Connell, Malaney R., et al.
Publicado: (2015)

The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
por: Liu, Ning Qing, et al.
Publicado: (2017)

Co-localization of autophagy-related protein p62 with cancer stem cell marker dclk1 may hamper dclk1's elimination during colon cancer development and progression
por: Roy, Badal Chandra, et al.
Publicado: (2019)

Molecular Mechanism of Mutational Disruption of DCLK1 Autoinhibition Provides a Rationale for Inhibitor Screening
por: Chen, Weizhi, et al.
Publicado: (2023)

DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder
por: Håvik, Bjarte, et al.
Publicado: (2012)

Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs
por: Zygmunt, Magdalena, et al.
Publicado: (2018)

Regulatory Roles of Dclk1 in Epithelial Mesenchymal Transition and Cancer Stem Cells
por: Chandrakesan, P, et al.
Publicado: (2016)

DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer
por: Vijai, Muthu, et al.
Publicado: (2021)

DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis
por: Roy, Badal C., et al.
Publicado: (2021)

Tn antigen promotes human colorectal cancer metastasis via H‐Ras mediated epithelial‐mesenchymal transition activation
por: Liu, Zhe, et al.
Publicado: (2019)

DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma
por: Wang, Hui, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_29qud4rbiojvrb7e1o6o5rgfr8