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Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas

This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43...

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Autores principales: Yao, Xiaohui, Zhang, Yazhuo, Wu, Lijuan, Cheng, Rui, Li, Chuzhong, Qu, Chongxiao, Ji, Hongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541973/
https://www.ncbi.nlm.nih.gov/pubmed/31223310
http://dx.doi.org/10.1155/2019/5731639
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author Yao, Xiaohui
Zhang, Yazhuo
Wu, Lijuan
Cheng, Rui
Li, Chuzhong
Qu, Chongxiao
Ji, Hongming
author_facet Yao, Xiaohui
Zhang, Yazhuo
Wu, Lijuan
Cheng, Rui
Li, Chuzhong
Qu, Chongxiao
Ji, Hongming
author_sort Yao, Xiaohui
collection PubMed
description This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases that included primary NFPA. A total of 31 paired patient samples were evaluated (12 patients with one surgery and 31 who had undergone two operations, with both tumors analyzed). Expressions of nuclear receptor subfamily 2 group C member 2 (NR2C2), B cell translocation gene 2, T-box-19 (TBX19), and cyclin-dependent kinase 2 (CDK2) in surgically resected specimens were assessed by immunohistochemistry. The relationships between marker expression and clinical characteristics including age, sex, tumor volume, and follow-up time were analyzed. Tumor volume and invasion as well as follow-up time were significantly associated with invasion and recurrence (P < 0.01). Of the 60 nonrecurrent samples, 15/41 and 13/19 showed high NR2C2 expression in the noninvasion and invasion groups, respectively (χ(2) =5.287, P = 0.021). NR2C2 was also overexpressed in 43 primary recurrent cases (χ(2) =5.433, P = 0.02), whereas CDK2 (χ(2) = 11.242, P = 0.001) and TBX19 (χ(2) = 4.875, P = 0.027) were downregulated. In the 31 paired samples, NR2C2 was more highly expressed in the recurrent as compared to the primary tumor. High NR2C2 expression was associated with NFPA invasion, recurrence, and progression, while TBX19 and CDK2 were associated with NFPA recurrence.
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spelling pubmed-65419732019-06-20 Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas Yao, Xiaohui Zhang, Yazhuo Wu, Lijuan Cheng, Rui Li, Chuzhong Qu, Chongxiao Ji, Hongming Int J Endocrinol Research Article This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases that included primary NFPA. A total of 31 paired patient samples were evaluated (12 patients with one surgery and 31 who had undergone two operations, with both tumors analyzed). Expressions of nuclear receptor subfamily 2 group C member 2 (NR2C2), B cell translocation gene 2, T-box-19 (TBX19), and cyclin-dependent kinase 2 (CDK2) in surgically resected specimens were assessed by immunohistochemistry. The relationships between marker expression and clinical characteristics including age, sex, tumor volume, and follow-up time were analyzed. Tumor volume and invasion as well as follow-up time were significantly associated with invasion and recurrence (P < 0.01). Of the 60 nonrecurrent samples, 15/41 and 13/19 showed high NR2C2 expression in the noninvasion and invasion groups, respectively (χ(2) =5.287, P = 0.021). NR2C2 was also overexpressed in 43 primary recurrent cases (χ(2) =5.433, P = 0.02), whereas CDK2 (χ(2) = 11.242, P = 0.001) and TBX19 (χ(2) = 4.875, P = 0.027) were downregulated. In the 31 paired samples, NR2C2 was more highly expressed in the recurrent as compared to the primary tumor. High NR2C2 expression was associated with NFPA invasion, recurrence, and progression, while TBX19 and CDK2 were associated with NFPA recurrence. Hindawi 2019-05-16 /pmc/articles/PMC6541973/ /pubmed/31223310 http://dx.doi.org/10.1155/2019/5731639 Text en Copyright © 2019 Xiaohui Yao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yao, Xiaohui
Zhang, Yazhuo
Wu, Lijuan
Cheng, Rui
Li, Chuzhong
Qu, Chongxiao
Ji, Hongming
Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas
title Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas
title_full Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas
title_fullStr Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas
title_full_unstemmed Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas
title_short Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas
title_sort immunohistochemical study of nr2c2, btg2, tbx19, and cdk2 expression in 31 paired primary/recurrent nonfunctioning pituitary adenomas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541973/
https://www.ncbi.nlm.nih.gov/pubmed/31223310
http://dx.doi.org/10.1155/2019/5731639
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