Early effects of roflumilast on insulin sensitivity in adults with prediabetes and overweight/obesity involve age-associated fat mass loss – results of an exploratory study

PURPOSE: Roflumilast (Daliresp, Daxas) is a FDA-approved phosphodiesterase 4 (PDE4) inhibitor for the treatment of moderate-to-severe chronic obstructive pulmonary disease. In mice and in limited human studies, this oral medication can cause weight loss and improve insulin sensitivity. We set out to...

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Detalles Bibliográficos
Autores principales: Muo, Ijeoma M, MacDonald, Sandra D, Madan, Ritu, Park, Sung-Jun, Gharib, Ahmed M, Martinez, Pedro E., Walter, Mary F, Yang, Shanna B, Rodante, Justin A, Courville, Amber B, Walter, Peter J, Cai, Hongyi, Glicksman, Michael, Guerrieri, Gioia M, Ben-Dor, Rivka R, Ouwerkerk, Ronald, Mao, Stephanie, Chung, Jay H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542328/
https://www.ncbi.nlm.nih.gov/pubmed/31213865
http://dx.doi.org/10.2147/DMSO.S182953

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