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Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke

BACKGROUND: Glial Fibrillary Acidic Protein (GFAP) is a protein produced by astrocytes in response to brain injury, which then penetrates the cerebrospinal fluid and the blood stream. AIM: We sought to determine whether GFAP serum level in acute ischemic stroke could predict clinical outcome. METHOD...

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Autores principales: Puspitasari, Vivien, Gunawan, Pricilla Yani, Wiradarma, Hugo Dwiputra, Hartoyo, Vinson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542382/
https://www.ncbi.nlm.nih.gov/pubmed/31198457
http://dx.doi.org/10.3889/oamjms.2019.326
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author Puspitasari, Vivien
Gunawan, Pricilla Yani
Wiradarma, Hugo Dwiputra
Hartoyo, Vinson
author_facet Puspitasari, Vivien
Gunawan, Pricilla Yani
Wiradarma, Hugo Dwiputra
Hartoyo, Vinson
author_sort Puspitasari, Vivien
collection PubMed
description BACKGROUND: Glial Fibrillary Acidic Protein (GFAP) is a protein produced by astrocytes in response to brain injury, which then penetrates the cerebrospinal fluid and the blood stream. AIM: We sought to determine whether GFAP serum level in acute ischemic stroke could predict clinical outcome. METHODS: As much as 64 patients with first-ever ischemic stroke had their GFAP serum level measured at 72 hours after onset. The National Institute of Health Stroke Scale (NIHSS) was assessed during the 72 hours of onset, the seventh day, and followed up 1 month after. RESULTS: There were 46 men and 18 women included in the study. Mean age was 58.3 years old, and nearly half of them (46.9%) were between 50-59 years old. More than half (58.7%) presented with moderate to a severe stroke and mean GFAP serum level was 0.113 ± 0.029 ng/mL. GFAP serum levels had a significant correlation with NIHSS after 1 month (p = 0.04, r = 0.259). CONCLUSION: There is a significant correlation between GFAP serum levels with stroke severity scale after 1 month of stroke onset.
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spelling pubmed-65423822019-06-13 Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke Puspitasari, Vivien Gunawan, Pricilla Yani Wiradarma, Hugo Dwiputra Hartoyo, Vinson Open Access Maced J Med Sci Clinical Science BACKGROUND: Glial Fibrillary Acidic Protein (GFAP) is a protein produced by astrocytes in response to brain injury, which then penetrates the cerebrospinal fluid and the blood stream. AIM: We sought to determine whether GFAP serum level in acute ischemic stroke could predict clinical outcome. METHODS: As much as 64 patients with first-ever ischemic stroke had their GFAP serum level measured at 72 hours after onset. The National Institute of Health Stroke Scale (NIHSS) was assessed during the 72 hours of onset, the seventh day, and followed up 1 month after. RESULTS: There were 46 men and 18 women included in the study. Mean age was 58.3 years old, and nearly half of them (46.9%) were between 50-59 years old. More than half (58.7%) presented with moderate to a severe stroke and mean GFAP serum level was 0.113 ± 0.029 ng/mL. GFAP serum levels had a significant correlation with NIHSS after 1 month (p = 0.04, r = 0.259). CONCLUSION: There is a significant correlation between GFAP serum levels with stroke severity scale after 1 month of stroke onset. Republic of Macedonia 2019-05-14 /pmc/articles/PMC6542382/ /pubmed/31198457 http://dx.doi.org/10.3889/oamjms.2019.326 Text en Copyright: © 2019 Vivien Puspitasari, Pricilla Yani Gunawan, Hugo Dwiputra Wiradarma, Vinson Hartoyo. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Clinical Science
Puspitasari, Vivien
Gunawan, Pricilla Yani
Wiradarma, Hugo Dwiputra
Hartoyo, Vinson
Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke
title Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke
title_full Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke
title_fullStr Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke
title_full_unstemmed Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke
title_short Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke
title_sort glial fibrillary acidic protein serum level as a predictor of clinical outcome in ischemic stroke
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542382/
https://www.ncbi.nlm.nih.gov/pubmed/31198457
http://dx.doi.org/10.3889/oamjms.2019.326
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