ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity

MAPK signaling consists of an array of successively acting kinases. ERK1 and -2 (ERK1/2) are major components of the greater MAPK cascade that transduce growth factor signaling at the cell membrane. Here, we investigated ERK1/2 signaling in skeletal muscle homeostasis and disease. Using mouse geneti...

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Detalles Bibliográficos
Autores principales: Boyer, Justin G., Prasad, Vikram, Song, Taejeong, Lee, Donghoon, Fu, Xing, Grimes, Kelly M., Sargent, Michelle A., Sadayappan, Sakthivel, Molkentin, Jeffery D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542606/
https://www.ncbi.nlm.nih.gov/pubmed/30964448
http://dx.doi.org/10.1172/jci.insight.127356

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