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Dose-response association of serum alanine aminotransferase levels with multimorbidity

Multimorbidity has posed a major challenge to health care systems worldwide, but little is known about its association with biological factors. This study represents the first one to examine the association of serum levels of alanine aminotransferase (ALT) with multimorbidity. The baseline category...

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Autores principales: Zhang, Yuxia, Yu, Lugang, Wang, Xiaoying, Qin, Liqiang, Shen, Yueping, Ke, Chaofu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542794/
https://www.ncbi.nlm.nih.gov/pubmed/31147585
http://dx.doi.org/10.1038/s41598-019-44510-x
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author Zhang, Yuxia
Yu, Lugang
Wang, Xiaoying
Qin, Liqiang
Shen, Yueping
Ke, Chaofu
author_facet Zhang, Yuxia
Yu, Lugang
Wang, Xiaoying
Qin, Liqiang
Shen, Yueping
Ke, Chaofu
author_sort Zhang, Yuxia
collection PubMed
description Multimorbidity has posed a major challenge to health care systems worldwide, but little is known about its association with biological factors. This study represents the first one to examine the association of serum levels of alanine aminotransferase (ALT) with multimorbidity. The baseline category logistic regression model was used to estimate the odds ratio (OR) between ALT and multimorbidity, and the area under the receiver operating characteristic curve (AUC) was used to evaluate the classification utility of ALT. Serum ALT levels were associated, in a dose-response manner, with multimorbidity. Compared with the first quartile, the adjusted OR (95% confidence interval) of the fourth quartile for multimorbidity was 4.71 (3.56–6.23). In addition, the AUC value for distinguishing the multimorbidity group from the control group reached 0.7185. In conclusion, high levels of ALT were significantly correlated with multimorbidity and this association was independent of other potential risk factors. Serum ALT might be a useful marker for identifying individuals with multimorbidity.
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spelling pubmed-65427942019-06-07 Dose-response association of serum alanine aminotransferase levels with multimorbidity Zhang, Yuxia Yu, Lugang Wang, Xiaoying Qin, Liqiang Shen, Yueping Ke, Chaofu Sci Rep Article Multimorbidity has posed a major challenge to health care systems worldwide, but little is known about its association with biological factors. This study represents the first one to examine the association of serum levels of alanine aminotransferase (ALT) with multimorbidity. The baseline category logistic regression model was used to estimate the odds ratio (OR) between ALT and multimorbidity, and the area under the receiver operating characteristic curve (AUC) was used to evaluate the classification utility of ALT. Serum ALT levels were associated, in a dose-response manner, with multimorbidity. Compared with the first quartile, the adjusted OR (95% confidence interval) of the fourth quartile for multimorbidity was 4.71 (3.56–6.23). In addition, the AUC value for distinguishing the multimorbidity group from the control group reached 0.7185. In conclusion, high levels of ALT were significantly correlated with multimorbidity and this association was independent of other potential risk factors. Serum ALT might be a useful marker for identifying individuals with multimorbidity. Nature Publishing Group UK 2019-05-30 /pmc/articles/PMC6542794/ /pubmed/31147585 http://dx.doi.org/10.1038/s41598-019-44510-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Yuxia
Yu, Lugang
Wang, Xiaoying
Qin, Liqiang
Shen, Yueping
Ke, Chaofu
Dose-response association of serum alanine aminotransferase levels with multimorbidity
title Dose-response association of serum alanine aminotransferase levels with multimorbidity
title_full Dose-response association of serum alanine aminotransferase levels with multimorbidity
title_fullStr Dose-response association of serum alanine aminotransferase levels with multimorbidity
title_full_unstemmed Dose-response association of serum alanine aminotransferase levels with multimorbidity
title_short Dose-response association of serum alanine aminotransferase levels with multimorbidity
title_sort dose-response association of serum alanine aminotransferase levels with multimorbidity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542794/
https://www.ncbi.nlm.nih.gov/pubmed/31147585
http://dx.doi.org/10.1038/s41598-019-44510-x
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