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Dose-response association of serum alanine aminotransferase levels with multimorbidity
Multimorbidity has posed a major challenge to health care systems worldwide, but little is known about its association with biological factors. This study represents the first one to examine the association of serum levels of alanine aminotransferase (ALT) with multimorbidity. The baseline category...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542794/ https://www.ncbi.nlm.nih.gov/pubmed/31147585 http://dx.doi.org/10.1038/s41598-019-44510-x |
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author | Zhang, Yuxia Yu, Lugang Wang, Xiaoying Qin, Liqiang Shen, Yueping Ke, Chaofu |
author_facet | Zhang, Yuxia Yu, Lugang Wang, Xiaoying Qin, Liqiang Shen, Yueping Ke, Chaofu |
author_sort | Zhang, Yuxia |
collection | PubMed |
description | Multimorbidity has posed a major challenge to health care systems worldwide, but little is known about its association with biological factors. This study represents the first one to examine the association of serum levels of alanine aminotransferase (ALT) with multimorbidity. The baseline category logistic regression model was used to estimate the odds ratio (OR) between ALT and multimorbidity, and the area under the receiver operating characteristic curve (AUC) was used to evaluate the classification utility of ALT. Serum ALT levels were associated, in a dose-response manner, with multimorbidity. Compared with the first quartile, the adjusted OR (95% confidence interval) of the fourth quartile for multimorbidity was 4.71 (3.56–6.23). In addition, the AUC value for distinguishing the multimorbidity group from the control group reached 0.7185. In conclusion, high levels of ALT were significantly correlated with multimorbidity and this association was independent of other potential risk factors. Serum ALT might be a useful marker for identifying individuals with multimorbidity. |
format | Online Article Text |
id | pubmed-6542794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65427942019-06-07 Dose-response association of serum alanine aminotransferase levels with multimorbidity Zhang, Yuxia Yu, Lugang Wang, Xiaoying Qin, Liqiang Shen, Yueping Ke, Chaofu Sci Rep Article Multimorbidity has posed a major challenge to health care systems worldwide, but little is known about its association with biological factors. This study represents the first one to examine the association of serum levels of alanine aminotransferase (ALT) with multimorbidity. The baseline category logistic regression model was used to estimate the odds ratio (OR) between ALT and multimorbidity, and the area under the receiver operating characteristic curve (AUC) was used to evaluate the classification utility of ALT. Serum ALT levels were associated, in a dose-response manner, with multimorbidity. Compared with the first quartile, the adjusted OR (95% confidence interval) of the fourth quartile for multimorbidity was 4.71 (3.56–6.23). In addition, the AUC value for distinguishing the multimorbidity group from the control group reached 0.7185. In conclusion, high levels of ALT were significantly correlated with multimorbidity and this association was independent of other potential risk factors. Serum ALT might be a useful marker for identifying individuals with multimorbidity. Nature Publishing Group UK 2019-05-30 /pmc/articles/PMC6542794/ /pubmed/31147585 http://dx.doi.org/10.1038/s41598-019-44510-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhang, Yuxia Yu, Lugang Wang, Xiaoying Qin, Liqiang Shen, Yueping Ke, Chaofu Dose-response association of serum alanine aminotransferase levels with multimorbidity |
title | Dose-response association of serum alanine aminotransferase levels with multimorbidity |
title_full | Dose-response association of serum alanine aminotransferase levels with multimorbidity |
title_fullStr | Dose-response association of serum alanine aminotransferase levels with multimorbidity |
title_full_unstemmed | Dose-response association of serum alanine aminotransferase levels with multimorbidity |
title_short | Dose-response association of serum alanine aminotransferase levels with multimorbidity |
title_sort | dose-response association of serum alanine aminotransferase levels with multimorbidity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542794/ https://www.ncbi.nlm.nih.gov/pubmed/31147585 http://dx.doi.org/10.1038/s41598-019-44510-x |
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