Cargando…
Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis
With the rapid development of tissue engineering therapies, there is a growing interest in the application of recombinant human growth factors (rhGFs) to regenerate human orofacial bones. However, despite reports of their ability to promote orofacial bone regeneration in animal experiments, their be...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542831/ https://www.ncbi.nlm.nih.gov/pubmed/31147568 http://dx.doi.org/10.1038/s41598-019-44368-z |
_version_ | 1783422992920870912 |
---|---|
author | Li, Feifei Yu, Fanyuan Liao, Xueyang Wu, Chenzhou Wang, Yitian Li, Chunjie Lou, Feng Li, Boer Yin, Bei Wang, Chenglin Ye, Ling |
author_facet | Li, Feifei Yu, Fanyuan Liao, Xueyang Wu, Chenzhou Wang, Yitian Li, Chunjie Lou, Feng Li, Boer Yin, Bei Wang, Chenglin Ye, Ling |
author_sort | Li, Feifei |
collection | PubMed |
description | With the rapid development of tissue engineering therapies, there is a growing interest in the application of recombinant human growth factors (rhGFs) to regenerate human orofacial bones. However, despite reports of their ability to promote orofacial bone regeneration in animal experiments, their benefits in human clinical treatments remain unclear. Furthermore, the appropriate concentrations or indications of a specific rhGF remain ambiguous. Therefore it is essential to collect data from diverse clinical trials to evaluate their effects more precisely. Here we reviewed randomized clinical trials (RCT) that focused on the utilization of rhGFs in orofacial bone regeneration. Data from included studies were extracted, pooled and then quantitatively analyzed according to a pre-established protocol. Our results indicate that all current concentrations of rhBMP-2 produces insufficient effect on promoting either tooth extraction socket healing, sinus augmentation or reconstruction of alveolar clefts. However, 0.3 mg/ml rhPDGF-BB promotes the healing of tooth extraction sockets, though the effect does not reach a level of statistical significance. Summarily, we recommend concentrations of 0.3 mg/ml rhPDGF-BB only for the healing of tooth extraction sockets. |
format | Online Article Text |
id | pubmed-6542831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65428312019-06-07 Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis Li, Feifei Yu, Fanyuan Liao, Xueyang Wu, Chenzhou Wang, Yitian Li, Chunjie Lou, Feng Li, Boer Yin, Bei Wang, Chenglin Ye, Ling Sci Rep Article With the rapid development of tissue engineering therapies, there is a growing interest in the application of recombinant human growth factors (rhGFs) to regenerate human orofacial bones. However, despite reports of their ability to promote orofacial bone regeneration in animal experiments, their benefits in human clinical treatments remain unclear. Furthermore, the appropriate concentrations or indications of a specific rhGF remain ambiguous. Therefore it is essential to collect data from diverse clinical trials to evaluate their effects more precisely. Here we reviewed randomized clinical trials (RCT) that focused on the utilization of rhGFs in orofacial bone regeneration. Data from included studies were extracted, pooled and then quantitatively analyzed according to a pre-established protocol. Our results indicate that all current concentrations of rhBMP-2 produces insufficient effect on promoting either tooth extraction socket healing, sinus augmentation or reconstruction of alveolar clefts. However, 0.3 mg/ml rhPDGF-BB promotes the healing of tooth extraction sockets, though the effect does not reach a level of statistical significance. Summarily, we recommend concentrations of 0.3 mg/ml rhPDGF-BB only for the healing of tooth extraction sockets. Nature Publishing Group UK 2019-05-30 /pmc/articles/PMC6542831/ /pubmed/31147568 http://dx.doi.org/10.1038/s41598-019-44368-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Li, Feifei Yu, Fanyuan Liao, Xueyang Wu, Chenzhou Wang, Yitian Li, Chunjie Lou, Feng Li, Boer Yin, Bei Wang, Chenglin Ye, Ling Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis |
title | Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis |
title_full | Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis |
title_fullStr | Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis |
title_full_unstemmed | Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis |
title_short | Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis |
title_sort | efficacy of recombinant human bmp2 and pdgf-bb in orofacial bone regeneration: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542831/ https://www.ncbi.nlm.nih.gov/pubmed/31147568 http://dx.doi.org/10.1038/s41598-019-44368-z |
work_keys_str_mv | AT lifeifei efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT yufanyuan efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT liaoxueyang efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT wuchenzhou efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT wangyitian efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT lichunjie efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT loufeng efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT liboer efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT yinbei efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT wangchenglin efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis AT yeling efficacyofrecombinanthumanbmp2andpdgfbbinorofacialboneregenerationasystematicreviewandmetaanalysis |