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A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking

BACKGROUND: Alcohol misuse often manifests in two different patterns of drinking; Binge Drinking (BD; ≥4 (women) or ≥ 5 (men) drinks/day, ≤12 days/month) or Heavy Drinking (HD; ≥3 (women) or ≥4 (men) drinks/day, ≥16 days/month). Although direct comparisons have not been made, structural MRI studies...

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Autores principales: Maksimovskiy, Arkadiy L., Fortier, Catherine B., Milberg, William P., McGlinchey, Regina E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542838/
https://www.ncbi.nlm.nih.gov/pubmed/31193798
http://dx.doi.org/10.1016/j.abrep.2019.100168
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author Maksimovskiy, Arkadiy L.
Fortier, Catherine B.
Milberg, William P.
McGlinchey, Regina E.
author_facet Maksimovskiy, Arkadiy L.
Fortier, Catherine B.
Milberg, William P.
McGlinchey, Regina E.
author_sort Maksimovskiy, Arkadiy L.
collection PubMed
description BACKGROUND: Alcohol misuse often manifests in two different patterns of drinking; Binge Drinking (BD; ≥4 (women) or ≥ 5 (men) drinks/day, ≤12 days/month) or Heavy Drinking (HD; ≥3 (women) or ≥4 (men) drinks/day, ≥16 days/month). Although direct comparisons have not been made, structural MRI studies indicate that the two types of drinking behaviors might be associated with different neuromorphometric characteristics. METHODS: This study used a cross-sectional design to compare brain structure (using MRI derived subcortical volume and cortical thickness measures) between participants with histories of BD (N = 16), HD (N = 15), and Healthy Controls (HC; N = 21). Whole-brain analyses were used to quantify group differences in subcortical volume and cortical thickness. Resulting cortical thickness clusters were quantified for their areas of overlap with resting-state network parcellations. RESULTS: BD was associated with decreased volumes of the bilateral global pallidus and decreased cortical thickness within the left superior-parietal cluster (p < .05). This cortical cluster overlapped in surface area with the dorsal-attention (50.86%) and the fronto-parietal network parcellations (49.14%). HD was associated with increased cortical thickness in the left medial occipito-parietal cluster (p < .05). This cluster primarily overlapped with the visual network parcellation (89%) and, to a lesser extent, with a widespread number of network parcellations (dorsal-attention: 3.8%; fronto-parietal: 3.5%; default-mode: 3.2%). CONCLUSIONS: These data indicate that histories of BD and HD patterns are associated with distinct neuromorphometric characteristics. BD was associated with changes within the executive control networks and the globus pallidus. HD was associated with widespread changes, that are primarily localized within the visual network.
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spelling pubmed-65428382019-06-03 A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking Maksimovskiy, Arkadiy L. Fortier, Catherine B. Milberg, William P. McGlinchey, Regina E. Addict Behav Rep Research paper BACKGROUND: Alcohol misuse often manifests in two different patterns of drinking; Binge Drinking (BD; ≥4 (women) or ≥ 5 (men) drinks/day, ≤12 days/month) or Heavy Drinking (HD; ≥3 (women) or ≥4 (men) drinks/day, ≥16 days/month). Although direct comparisons have not been made, structural MRI studies indicate that the two types of drinking behaviors might be associated with different neuromorphometric characteristics. METHODS: This study used a cross-sectional design to compare brain structure (using MRI derived subcortical volume and cortical thickness measures) between participants with histories of BD (N = 16), HD (N = 15), and Healthy Controls (HC; N = 21). Whole-brain analyses were used to quantify group differences in subcortical volume and cortical thickness. Resulting cortical thickness clusters were quantified for their areas of overlap with resting-state network parcellations. RESULTS: BD was associated with decreased volumes of the bilateral global pallidus and decreased cortical thickness within the left superior-parietal cluster (p < .05). This cortical cluster overlapped in surface area with the dorsal-attention (50.86%) and the fronto-parietal network parcellations (49.14%). HD was associated with increased cortical thickness in the left medial occipito-parietal cluster (p < .05). This cluster primarily overlapped with the visual network parcellation (89%) and, to a lesser extent, with a widespread number of network parcellations (dorsal-attention: 3.8%; fronto-parietal: 3.5%; default-mode: 3.2%). CONCLUSIONS: These data indicate that histories of BD and HD patterns are associated with distinct neuromorphometric characteristics. BD was associated with changes within the executive control networks and the globus pallidus. HD was associated with widespread changes, that are primarily localized within the visual network. Elsevier 2019-02-19 /pmc/articles/PMC6542838/ /pubmed/31193798 http://dx.doi.org/10.1016/j.abrep.2019.100168 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research paper
Maksimovskiy, Arkadiy L.
Fortier, Catherine B.
Milberg, William P.
McGlinchey, Regina E.
A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking
title A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking
title_full A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking
title_fullStr A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking
title_full_unstemmed A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking
title_short A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking
title_sort structural mri study of differential neuromorphometric characteristics of binge and heavy drinking
topic Research paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542838/
https://www.ncbi.nlm.nih.gov/pubmed/31193798
http://dx.doi.org/10.1016/j.abrep.2019.100168
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