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Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing
The determination of null- or low-expressed HLA alleles is clinically relevant in both hematopoietic stem cell transplantation and solid organ transplantation. We studied the expression level of a questionable (Q) HLA-B*38:68Q allele, which carries a 9-nucleotide (nt) deletion at codon 230–232 in ex...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542842/ https://www.ncbi.nlm.nih.gov/pubmed/31147565 http://dx.doi.org/10.1038/s41598-019-44336-7 |