Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts

The Wnt/β-catenin signalling pathway is essential for intestinal epithelium homeostasis, but its aberrant activation is a hallmark of colorectal cancer (CRC). Several studies indicate that the bioactive vitamin D metabolite 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferrer-Mayorga, Gemma, Niell, Núria, Cantero, Ramón, González-Sancho, José Manuel, del Peso, Luis, Muñoz, Alberto, Larriba, María Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542853/
https://www.ncbi.nlm.nih.gov/pubmed/31147591
http://dx.doi.org/10.1038/s41598-019-44574-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542853/
https://www.ncbi.nlm.nih.gov/pubmed/31147591
http://dx.doi.org/10.1038/s41598-019-44574-9

Ejemplares similares